Nowadays, postoperative wound complications are quite frequent in surgery. Various medicines and physical methods are widely used to accelerate reparative regeneration (1,2). So far, the effect of oxygen air ions on the wound healing process has not been studied. Meanwhile, aeroionotherapy, characterized by an anti-oxidant action, can have an inducer effect.The purpose of the research was to study the effect of oxygen air ions on the regeneration of tissue structures of a laparotomic wound. Clinical and laboratory studies were conducted in 48 patients (divided into two groups) with acute peritonitis of appendicular origin. The patients of the basic group underwent aerorionotherapy in the early postoperative period. While using aeroionotherapy, the reparative process was faster and more perfect. The effect of oxygen air ions was accompanied by an acceleration of the inflammatory reaction course, which is manifested by the rapid migration of cellular elements to the wound surface and their differentiation into the connective tissues. This important fact explains the anti-inflammatory effect of such therapy, its capability to inhibit the alterative process and stimulate the reparative process. In the basic group, the intensity of biological consolidation was significantly different from that of the comparison group. Only 3 days after the operation, it was higher than the control value by 23.2%, after 5 days - by 37.7%, after 7 days - by 35.6% (p <0.01). Thus, the obtained data suggest that the negative oxygen air ions should have a rather pronounced regenerative effect.