Manganese-doped Mesoporous Silica Nanopowder for Pharmaceutical Applications

Abstract

The purpose of the research was to produce and analyze properties of manganesedoped mesoporous silica nanopowder (NP) for biomedical applications. SiO2-MnO2 NP were produced by pulsed electron evaporation demonstrated high porosity amorphous structure, magnetic properties increased with addition of dopant. The toxicity experiments on cells showed that SiO2-MnO2 NP exerted low toxicity. Loading experiments showed qualitative interaction of antibiotic “Amoxicillin” with NP surface. According to obtained properties, produced SiO2-MnO2mesoporous NP is potential material for creating targeted drug delivering system.


Keywords: mesoporous silica nanopowder, doped with manganese dioxide, targeted drug delivery.

References
[1] A. Ito, M. Shinkai, H. Honda, T. Kobayashi,“Medical Application of Functionalized Magnetic Nanoparticles,“Journal Of Bioscience And Bioengineering, no. 1, pp. 1-11, 2005.


[2] Q. Pankhurst, J. Connolly, S. Jones, J. Dobson, “Applications of magnetic nanoparticles in biomedicine,” Journal of physics, vol. 36, pp. 167-181, 2003.


[3] Usov V.Yu., Belyanin M.L., Borodin O.Yu. et al. “Use of Mndiethylentriaminpentaacetate comparison with Gd-DTPA,“Meditsinskaya vizualizatsija, no. 4, pp. 134–142, 2008. (in Russian)


[4] Y. Song, Y. Li, Q. Xu et al., “Mesoporous silica nanoparticles for stimuli - responsive controlled drug delivery: advances, challenges, and outlook,“International Journal of Nanomedicine, vol. 12, pp. 1-24, 2016.


[5] S. Yu. Sokovnin, V. Il’ves, “Production of nanopowders using pulsed electron beam,“Ferroelectrics, pp. 101-107, 2012. (ID: 730951 DOI:10.1080/10584587.2012.730951)


[6] M. Arruebo, R. Fernandez-Pacheco, M. Ricardo Ibarra,”Magnetic nanoparticles for drug delivery,” Nanotoday, pp. 22-32, 2017.


[7] E. I. Cherkasova, A.A. Brilkina, “The work with cell cultures,“Tutorial, Nizhny Novgorod, pp. 57, 2015. (in Russian)


[8] V. G. Alexeev, “Bioorganic chemistry of penicillins and cephalosporins,“Tutorial, Tver, pp. 104, 2009.