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Zinovyev, S. V., Saprikina, N. S., Kargina, J. V., Le-Deygen, I. M., Sviridov, A. P., Bazylenko, T. Y., Fesenko, I. K., & Timoshenko, V. Y. (2018). In-vivo Studies of Ultrasound-activated Drug-loaded Porous Silicon Nanoparticles for Cancer Therapy Application. KnE Energy, 3(2), 556–562. https://doi.org/10.18502/ken.v3i2.1865

https://doi.org/10.18502/ken.v3i2.1865

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authors

  • S V Zinovyev
    No author data available.
  • N S Saprikina
    No author data available.
  • J V Kargina
    No author data available.
  • I M Le-Deygen
    No author data available.
  • A P Sviridov
    No author data available.
  • T Yu Bazylenko
    No author data available.
  • I K Fesenko
    No author data available.
  • V Yu Timoshenko
    No author data available.

Published Date

  • Apr 17, 2018

In-vivo Studies of Ultrasound-activated Drug-loaded Porous Silicon Nanoparticles for Cancer Therapy Application

KnE Energy / The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine" / Pages 556–562

Abstract

It is investigated the therapeutic efficacy of combined action of ultrasound and porous silicon nanoparticles loaded with anticancer drug doxorubicin by using an experimental cancer model of lung Lewis carcinoma in vivo. Time dependences of growth of the primary tumor with introduced nanoparticles and without them, as well as the life span of mice after exposure to therapeutic ultrasound with intensity of 1W/cm2 and frequency of 1 MHz were studied. The obtained results show the effectiveness of inhibiting the growth of primary tumor site, as well as slowing the process of metastasis, in the case of combined action of ultrasound and drug-loaded porous silicon nanoparticles that indicates the prospect of latter as sonosensitizers and nanocontainers for the delivery and controlled release of drugs in sonodynamic therapy of malignant tumors.


Keywords: silicon nanoparticles, nanocontainers, medical ultrasound, sonodynamic therapy, sonosensitizers

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