Download fulltext HTML
Sadykhov, E. G., Gulyaev, M. V., Anisimov, N. V., Pirogov, Y. A., & Belyaev, V. N. (2018). Sodium-23 Magnetic Resonance Imaging. KnE Energy, 3(2), 441–448. https://doi.org/10.18502/ken.v3i2.1849

https://doi.org/10.18502/ken.v3i2.1849

statistics

  • 505 Abstract Views
  • 397 PDF Views
  • 0 HTML Views

authors

  • E G Sadykhov
    No author data available.
  • M V Gulyaev
    No author data available.
  • N V Anisimov
    No author data available.
  • Yu A Pirogov
    No author data available.
  • V N Belyaev
    No author data available.

Published Date

  • Apr 17, 2018

Sodium-23 Magnetic Resonance Imaging

KnE Energy / The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine" / Pages 441–448

Abstract

23Na MRI provides additional biochemical information to 1H MRI in terms of cell integrity and tissue viability. We aimed at determining the sensitivity of 23Na MRS, MRI and MR relaxometry methods available on 7T MR scanner Bruker Biospec 70/30 USR and developing of an optimal MRI protocol for small animal 23Na in vivo visualization. The outcomes include 23Na MR spectra, 23Na MR images with SNRs, and T1 and T2 values of 23Na. It is shown that single-pulse 23Na MR spectroscopy can discriminate different 23Na concentrations, and 3D FLASH pulse sequence adapted for 23Na data acquisition may provide the acceptable quality images.


Keywords: Sodium MRI, Sodium MRS, 3D FLASH, MR relaxometry

References
[1] M. Burnier, Sodium in Health and Disease. New York: Informa Healthcare USA, Inc.,2008.


[2] E. Murphy and D. Eisner, “Regulation of intracellular and mitochondrial sodium in health and disease,” Circ. Res., vol. 104, pp. 292–303, 2009.


[3] G. Madelin et al., “Sodium MRI: Methods and applications,” Prog. Nucl. Magn. Reson. Spectrosc., vol. 79, pp. 14–47, 2014.


[4] E. Staroswiecki et al., “In Vivo Sodium Imaging and Relaxometry of the Breast at 3T,” in Proc. Intl. Soc. Mag. Reson. Med. 17, 2009, p. 2129.


[5] M. Lupu et al., “IN VIVO SODIUM MRI RELAXOMETRY OF NORMAL AND PATHOLOGICAL MOUSE LIVER AT 4.7 T,” in Proc. Intl. Soc. Mag. Reson. Med. 15, 2007, p. 1329.


[6] C. Thomas et al., “Cisplatin treatment monitoring by sodium MRI relaxometry at 4.7 T in colorectal tumors implanted on mice,” in Proc. Intl. Soc. Mag. Reson. Med. 16,2008, p. 2795.


[7] G. Schneider, W. Rasband, and K. Eliceiri, “NIH Image to ImageJ: 25 years of image analysis,” Nat. Methods, vol. 9, pp. 671–675, 2012.


[8] O. Dietrich et al., “Measurement of Signal-to-Noise Ratios in MR Images: Influence of Multichannel Coils, Parallel Imaging, and Reconstruction Filters,” J. Magn. Reson. Imaging, vol. 26, pp. 375–385, 2007.


[9] R. Ernst and W. Anderson, “Application of Fourier transform spectroscopy to magnetic resonance,” Rev Sci Instrum, vol. 37, pp. 93–102, 1966.


[10] J. Christensen et al., “Quantitative tissue sodium concentration mapping of normal rat brain,” Magn. Reson. Med., vol. 36, pp. 83–89, 1996.


[11] Ouwerkerk R., “Sodium MRI,” Methods Mol. Biol., vol. 711, pp. 175–201, 2011.