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Petriev, V. M., Tishchenko, V. K., Smoryzanova, O. A., Bol’bit, N. M., Duflot, V. R., Morozova, N. B., & Yakubovskaya, R. I. (2018). Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153. KnE Energy, 3(2), 375–379. https://doi.org/10.18502/ken.v3i2.1839

https://doi.org/10.18502/ken.v3i2.1839

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authors

  • V M Petriev
    No author data available.
  • V K Tishchenko
    No author data available.
  • O A Smoryzanova
    No author data available.
  • N M Bol’bit
    No author data available.
  • V R Duflot
    No author data available.
  • N B Morozova
    No author data available.
  • R I Yakubovskaya
    No author data available.

Published Date

  • Apr 17, 2018

Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153

KnE Energy / The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine" / Pages 375–379

Abstract

This work is devoted to studying the in vivo antitumor efficacy of the new injection radiopharmaceutical based on thermoresponsive polymer and β−-emitting radionuclide samarium-153 (153Sm-KARP-CheM). The study of in vivo antitumor efficacy was performed using mice F1 and C57Bl/6 with transplanted subcutaneously sarcoma S37 and melanoma B16, respectively. The animals received single intratumoral bolus injections of 37 MBq (1 mCi), or 18.5 MBq (0.5 mCi) of 153Sm-KARP-CheM, or saline in a volume 0.1 ml. The efficacy of antitumortreatment was evaluated using tumor growth inhibition index (TGI, %) and increase of average life span (ILS, %). The most meaningful therapeutic efficacy after intratumoral injection of 153Sm-KARPCheM was observed in melanoma-bearing mice C57Bl/6. The highest values of TGI for melanoma B16 were 79.5% and 79.6% after treatment with 18.5 MBq or 37 MBq, respectively. An increase of average life span by 17.1% was found in group of melanoma-bearing mice treated with 37 MBq of 153Sm-KARP-CheM only. Tumor growth inhibition of sarcoma S37 was slightly lower as compared with melanoma B16: 62.5% and 59.0% in 37 MBq and 18.5 MBq groups, respectively. 153Sm-KARP-CheM didn’t increase average life span of treated animals. In conclusion, 153Sm-KARP-CheM seems to be effective radiopharmaceutical for local tumor radiotherapy.


Keywords: thermoresponsive polymer, samarium-153, radionuclide therapy of cancer, sarcoma S37, melanoma B16, antitumor efficacy.

References
[1] Vanparijs N., Nuhn L., De Geest B.G. Transiently thermoresponsive polymers and their applications in biomedicine. Chem. Soc. Rev., 2017, V. 46, No. 4, P. 1193–1239.


[2] Gandhi A., Paul A., Sen S.O., Sen K.K. Studies on thermoresponsive polymers: phase behaviour, drug delivery and biomedical applications. Asian J. Pharm. Sci., 2015, V. 10, P. 99–107.


[3] Haq M.A., Su Y., Wang D. Mechanical properties of PNIPAM based hydrogels: A review. Mater. Sci. Eng. C. Mater. Biol. Appl., 2017, V. 70(Pt 1), P. 842–855.


[4] Hruby M., Konak C., Kucka J., Vetrik M., Filippov S.K., Vetvicka D., Mackova H., Karlsson G., Edwards K., Rihova B., Ulbrich K. Thermoresponsive, hydrolytically degradable polymer micelles intended for radionuclide delivery. Macromol. Biosci., 2009, V. 9, P. 1016–1027.


[5] Kucka J., Hruby M., Lebeda O. Biodistribution of a radiolabelled thermoresponsive polymer in mice. Appl. Radiat. Isotopes., 2010, V. 68, P. 1073–1078.