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Mikulich, A. V., Tretyakova, A. I., Knukshto, V. N., Plavskaya, L. G., Leusenka, I. A., Ananich, T. S., Plavskii, V. Y., & Ulaschik, V. S. (2018). Potential of Antifungal Drugs as Photosensitizers. KnE Energy, 3(2), 223–231. https://doi.org/10.18502/ken.v3i2.1816

https://doi.org/10.18502/ken.v3i2.1816

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authors

  • A V Mikulich
    No author data available.
  • A I Tretyakova
    No author data available.
  • V N Knukshto
    No author data available.
  • L G Plavskaya
    No author data available.
  • I A Leusenka
    No author data available.
  • T S Ananich
    No author data available.
  • V Yu Plavskii
    No author data available.
  • V S Ulaschik
    No author data available.

Published Date

  • Apr 17, 2018

Potential of Antifungal Drugs as Photosensitizers

KnE Energy / The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine" / Pages 223–231

Abstract

In the present work, using commercially available formulation of polyene antifungal antibiotic amphotericin B, it is shown that its antifungal activity could be enhanced in combination with optical radiation corresponding to the absorption band of amphotericin B due to photodynamic effect. It is assumed that the radical processes dominate in the mechanism of photodynamic action in the presence of amphotericin B.


Keywords: Amphotericin B, antimicrobial/antifungal photodynamic therapy (aPDT), lactate dehydrogenase (LDH), singlet oxygen, laser, LEDs

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