Clinical Experience of Luminescent Diagnostics of Precancerous Diseases and Cervical Cancer
Abstract
The article summarizes the experience of using luminescent diagnostics with the use of ytterbium porphyrin complexes in gynecology and oncology. A pharmaceutical composition based on the Yb complex of 2,4-dimethoxyhematoporphyrin IX was used as the luminescent markers within the infrared range. The determination of luminescence characteristics (luminescence intensity) was carried out using a laserfiber fluorimeter in the range of 900-1100 nm. A new method for diagnosis of cervical disease has been proposed. The method of luminescent diagnostics allows to conduct a survey of a large number of patients in a short time. The method of luminescent diagnostics using the ytterbium complexes of porphyrins is not invasive. The method can be used as a screening. Differences between normal and pathologically altered cervical tissue have been identified and differences between pathological changes in the cervix HSIL (CIN II, CIN III) and cervical cancer are reliable.
Keywords: Cervical cancer, squamous cell carcinoma, diagnosis of cervical cancer, squamous intraepithelial lesions of high grade – HSIL, luminescent diagnostics, luminescing in the near infrared (NIR) spectral region, porphyrins, ytterbium complexes of porphyrins.
References
[1] Healthcare in Russia. 2015: Rosstat. - Moscow, 2015. - 174 p. ISBN 978-5-89476- 413-9 (in Russian)
[2] Kovaleva AM, Shilov IP, Ivanov AV, Alekseev Yu.V., Rumyantseva VD, Ivashov CA, Voznesensky VI, Pominalnaya VM, Ishchenko AI., Kovalev MI. NIR -luminescent diagnostics of pathological changes in the cervix. // Lasers in science, technology, medicine. Collection of scientific papers. Volume 28. Moscow, MNTORES, M., 2017, p.198-202. ISBN 978-5-902454-12-0 (in Russian)
[3] A.M. Kovaleva, A.I. Ischenko, M.I. Kovalev, I.P. Shilov, Yu.V. Alekseev, A.V. Ivanov, V.D.Rumyantseva, V.I.Voznesensky, V.M.Pominalnay. Luminescent diagnostics of precancer and cervical cancer.// Topical issues of modern medicine: materials of the II International Conference of the Caspian states, - Astrakhan: Publishing house of the Astrakhan State Medical University, 2017. - P. 91-93. ISBN 978-5-4424-0277- 3. (in Russian).
[4] M. Kovalev, A. Kovaleva, I. Shilov, A. Ivanov, Yu. Alekseev, V. Rumyantseva, V. Voznesensky, V. Pominalnaya, A. Ischenko. Luminescent diagnostics of pathological changes of the cervix. // Technologies for Biomedicine. The 2nd International Symposium October 10-14, 2017, Moscow, Russia, Book of abstracts. Moscow MEPhI, 2017. – p. 232-233. ISBN 978-5-7262-2417-6