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Fekri S, Rikhtehgar MH, Bagheri A, Veisi A, Akhavan Azari A. Presentation of Adult-onset Asthma and Periocular Xanthogranuloma with Intermediate Uveitis and Hodgkin’s Lymphoma: A Case Report. JOVR [Internet]. 2024Jun.21 [cited 2024Jun.30];19(2):255–259. Available from: https://knepublishing.com/index.php/JOVR/article/view/9629

https://doi.org/10.18502/jovr.v19i2.9629

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authors

  • Sahba Fekri

    Sahba Fekri

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    https://orcid.org/0000-0002-7388-6725
  • Mohamad Hasan Rikhtehgar

    Mohamad Hasan Rikhtehgar

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Abbas Bagheri

    Abbas Bagheri

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    https://orcid.org/0000-0002-6736-7435
  • Amirreza Veisi

    Amirreza Veisi

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    https://orcid.org/0000-0001-8304-3804
  • Amir Akhavan Azari

    Amir Akhavan Azari

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Published Date

  • Jun 21, 2024
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Presentation of Adult-onset Asthma and Periocular Xanthogranuloma with Intermediate Uveitis and Hodgkin’s Lymphoma: A Case Report

Journal of Ophthalmic and Vision Research (JOVR) / Apr–Jun 2024, Volume 19, Issue 2 / Pages 255–259

Abstract

Purpose: To report a case of adult-onset asthma and periocular xanthogranuloma (AAPOX) in a patient with intermediate uveitis and a history of Hodgkin’s lymphoma (HL).


Case Report: A 51-year-old man with a past medical history of HL presented with blurred vision, asthma, and bilateral yellowish eyelid lesions. The eyelid lesions and asthma appeared 10 years after being diagnosed with HL. Physical examination was significant for multiple subcutaneous and firm eyelid masses in addition to the presence of pre-auricular and submandibular lymphadenopathies. Ophthalmic examination revealed bilateral intermediate uveitis and mild macular edema. Further systemic evaluations, including laboratory testing and imaging, were normal. Excisional biopsy of the eyelid lesions was performed and the histopathologic examination was consistent with the diagnosis of AAPOX.


Conclusion: The presence of AAPOX in a patient with intermediate uveitis and history of HL suggests that immunological dysfunction may play a role in the pathogenesis of adult orbital xanthogranulomatous disease.

Keywords:

Adult-onset Asthma, Hodgkin Lymphoma, Intermediate Uveitis, Xanthogranuloma

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