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Karadag R, M. Hammersmith K, K. Nagra P, J. Rapuano C. Anterior Chamber Characteristics, Endothelial Parameters, and Corneal Densitometry After Descemet Stripping Automated Endothelial Keratoplasty in Patients With Fuchs Dystrophy. JOVR [Internet]. 2021Apr.29 [cited 2024Apr.25];16(2):158–164. Available from: https://knepublishing.com/index.php/JOVR/article/view/9078

https://doi.org/10.18502/jovr.v16i2.9078

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authors

  • Remzi Karadag

    Remzi Karadag

    Veni Vidi Eye Center, Istanbul, Turkey
  • Kristin M. Hammersmith

    Kristin M. Hammersmith

    Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA
  • Parveen K. Nagra

    Parveen K. Nagra

    Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA
  • Christopher J. Rapuano

    Christopher J. Rapuano

    Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA

Published Date

  • Apr 29, 2021
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Anterior Chamber Characteristics, Endothelial Parameters, and Corneal Densitometry After Descemet Stripping Automated Endothelial Keratoplasty in Patients With Fuchs Dystrophy

Journal of Ophthalmic and Vision Research (JOVR) / April–June 2021, Volume 16, Issue 2 / Pages 158–164

Abstract

Purpose: To compare anterior segment parameters in patients with Fuchs endothelial dystrophy (FED) who underwent Descemet stripping automated endothelial keratoplasty (DSAEK) in one eye and no corneal surgery in the fellow eye.


Methods: This prospective study was conducted on 28 eyes of 14 patients with FED who underwent DSAEK in one eye at least one year prior (DSAEK group) and no corneal surgery in the fellow eye (control group). Each eye was analyzed with the anterior segment optical coherence tomography, specular microscopy, and Scheimpflug imaging systems. Data were compared between the two groups.


Results: The mean age of the patients was 76.9 ± 7.0 years. There were no statistically significant differences in the mean central corneal thickness (CCT), central anterior chamber depth, anterior chamber angle parameters, cylinder and keratometry values between two groups (all P-values > 0.05). The paracentral corneal thickness, corneal volume, endothelial cell density, and hexagonal cell ratio measurements were statistically significantly higher in the DSAEK group than the control (all P-values < 0.05), and anterior chamber volume in the DSAEK group was significantly less than the control (P = 0.046). While posterior and total corneal densitometry values in the DSAEK group were statistically significantly lower than the control (P < 0.001 and P = 0.011, respectively), there were no statistically significant differences in the anterior or middle corneal densities (P = 0.108 and P = 0.134, respectively).


Conclusion: We found that total corneal densitometry value decreased in DSAEK group. Although DSAEK surgery did not affect the anterior chamber angle parameters, it reduced the anterior chamber volume and increased the corneal volume and paracentral corneal thickness due to the addition of the DSAEK graft.

Keywords:

Anterior Chamber Parameters, Corneal Densitometry, Corneal Thickness, Descemet Stripping Automated Endothelial Keratoplasty, DSAEK, Endothelial Cell, Fuchs Dystrophy

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