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Ndubuisi Okonkwo O, Olobola Hassan A, Akanbi T. Autologous Neurosensory Retinal Transplantation: A Report of Three Cases. JOVR [Internet]. 2021Jan.20 [cited 2024May5];16(1):68–76. Available from: https://knepublishing.com/index.php/JOVR/article/view/8252

https://doi.org/10.18502/jovr.v16i1.8252

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authors

  • Ogugua Ndubuisi Okonkwo

    Ogugua Ndubuisi Okonkwo

    Eye Foundation Hospital, Apo. Abuja, Nigeria
    https://orcid.org/0000-0002-6805-2427
  • Adekunle Olobola Hassan

    Adekunle Olobola Hassan

    Eye Foundation Hospital, Apo. Abuja, Nigeria
  • Toyin Akanbi

    Toyin Akanbi

    Eye Foundation Hospital, Apo. Abuja, Nigeria

Published Date

  • Jan 20, 2021
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Autologous Neurosensory Retinal Transplantation: A Report of Three Cases

Journal of Ophthalmic and Vision Research (JOVR) / January–March 2021, Volume 16, Issue 1 / Pages 68–76

Abstract

Purpose: To present the anatomical and functional outcomes of autologous surgical transplantation of a free neurosensory retinal graft in three cases of recurrent and chronic full thickness macular hole (MH).


Method: A retrospective case series, reporting the profile, preoperative presentation, surgical technique, and postoperative outcome of three consecutive eyes of three patients who had autologous retina transplantation (ART) surgery for recurrent and chronic MHs, and had a minimum of six months follow-up. The technique involved excision of a free neurosensory graft after laser demarcation of the harvest site. The graft was slid under perfluorocarbon liquid (PFCL) into the MH. A five-day tamponade with PFCL was used to secure the graft within the MH and then exchanged with air.


Results: The patients were one female and two males aged 60, 44, and 67 years, respectively. All eyes had a successful surgery. Postoperative vision improved from 6/36 to 6/18 in patient 1 and remained the same as a preoperative vision in the other two eyes. No eye lost vision postoperatively. The main complication of surgery was the occurrence of retinal and vitreous hemorrhage in one eye (this did not appear to jeopardize the outcome) and retraction of graft tissue in two eyes.


Conclusion: ART appears to be a safe and effective treatment for difficult MHs. Our results are comparable to previous studies. Short-term use of PFCL can be useful to secure the graft within the MH. Methods of improving visual function should be the focus of further research in this promising area.

Keywords:

Autologous Transplant, Macular Hole, Neurosensory Retina, Vitrectomy

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