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Bajwa A, Maleki A, Payal AR, Fandiño A, Padrón MIM, Walsh M, Foster CS. Efficacy and Safety of Infliximab in HLA-B27-associated Ocular Inflammation Refractory or Intolerant to Conventional Immunomodulatory Therapy. JOVR [Internet]. 2020Oct.25 [cited 2024Jul.17];15(4):459–469. Available from: https://knepublishing.com/index.php/JOVR/article/view/7786

https://doi.org/10.18502/jovr.v15i4.7786

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authors

  • Asima Bajwa

    Asima Bajwa

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts
  • Arash Maleki

    Arash Maleki

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts
  • Abhishek R Payal

    Abhishek R Payal

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts; University of Pennsylvania, Scheie Eye Institute, Philadelphia, Pennsylvania
  • Adriana Fandiño

    Adriana Fandiño

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts
  • María Inés Menéndez Padrón

    María Inés Menéndez Padrón

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts
  • Marisa Walsh

    Marisa Walsh

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts
  • Charles Stephen Foster

    Charles Stephen Foster

    Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Harvard Medical School, Boston, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts

Published Date

  • Oct 25, 2020
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Efficacy and Safety of Infliximab in HLA-B27-associated Ocular Inflammation Refractory or Intolerant to Conventional Immunomodulatory Therapy

Journal of Ophthalmic and Vision Research (JOVR) / October–December 2020, Volume 15, Issue 4 / Pages 459–469

Abstract

Purpose: To determine the efficacy and safety of infliximab therapy in patients with HLA B-27-associated ocular inflammation resistant or intolerant to conventional immunomodulatory therapy.


Methods: This was a retrospective observational case series. All cases were uveitic patients with positive HLA-B27, confirmed through HLA testing, resistant or intolerant to conventional immunomodulatory therapy. The primary outcome of the study was to identify the efficacy of infliximab determined by the control of inflammation, duration of remission, and the ability to reduce conventional immunomodulatory therapy. The secondary outcome was an improvement of two or more lines of best-corrected visual acuity (BCVA) on the Snellen visual acuity chart.


Results: Twenty-four patients (38 eyes) were included in the study. All patients were followed for 24 months. Twenty-one (87.5%) patients completed 24 months of follow-up. Sixteen (66.7%) patients had active uveitis at the beginning of therapy. One patient out of these active patients had active inflammation at the end of follow-up period. Thirteen (87.5%) out of sixteen active patients were in steroid-free remission. The mean duration of treatment to induce remission was 16.5 months (range 6–24 months). Corticosteroid was stopped in 19 (90.5%) patients by the end of the study. At the end of the study, in patients who achieved remission, 14 (58.3%) patients were in remission on infliximab therapy and 6 (25%) patients were in remission off infliximab therapy. Of the 38 eyes, 8 (21.05%) showed improvement in BCVA (three eyes had successful cataract extraction with intraocular lens implantation during infliximab therapy with no subsequent inflammation), while 26 eyes (68.4%) had stable BCVA over the 24-month study period. The side effects included allergic reaction, fatigue, cellulitis, headache, restlessness, elevation of liver enzymes, and anemia. Two patients (n = 24, 8.3%) experienced severe adverse effects and the treatment was stopped prematurely in these two patients.


Conclusion: Infliximab might induce and maintain the steroid-free remission in HLAB27- associated ocular inflammation in patients resistant or intolerant to conventional immunomodulatory therapy.

Keywords:

HLA-B27, Immunomodulatory Therapy, Infliximab, TNF-α, Uveitis, Vasculitis

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