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M. Zereid F, L. Osuagwu U. Myopia and Regional Variations in Retinal Thickness in Healthy Eyes. JOVR [Internet]. 2020Apr.6 [cited 2024Jul.17];15(2):178–186. Available from: https://knepublishing.com/index.php/JOVR/article/view/6735

https://doi.org/10.18502/jovr.v15i2.6735

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  • Cited by 4 articles

authors

  • Feryal M. Zereid

    Feryal M. Zereid

    Department of Optometry & Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
  • Uchechukwu L. Osuagwu

    Uchechukwu L. Osuagwu

    School of Medicine, Diabetes Obesity and Metabolism Translational Research Unit (DOMTRU), Macarthur Clinical School, Parkside Crescent, Campbelltown, Australia; African Vision Research Institute, University of KwaZulu-Natal, Durban, South Africa

Published Date

  • Apr 6, 2020
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Myopia and Regional Variations in Retinal Thickness in Healthy Eyes

Journal of Ophthalmic and Vision Research (JOVR) / April–June 2020, Volume 15, Issue 2 / Pages 178–186

Abstract

Purpose: To investigate the effects of refraction on retinal thickness measurements at different locations and layers in healthy eyes of Saudi participants.


Methods: Thirty-six randomly selected adults aged 27.0 ± 5.7 years who attended a Riyadh hospital from 2016 to 2017 were categorized into three groups: non-myopic (spherical equivalent refraction [SER], +1.00 to –0.50 diopters [D]), low myopic (SER, – 0.75 to –3.00D), and moderate to high myopic (SER ≤ –3.25D). Full, inner, and outer retinal thicknesses were measured at nine locations by spectral-domain stratus optical coherence tomography (Optovue Inc., Fremont, CA, USA) and were compared according to refractive group and sex.


Results: The mean SERs for the non-myopia, low myopia, and moderate to high myopia groups were 0.2 ± 0.6, –1.5 ± 0.5, and –7.5 ± 1.9 D, respectively. Refractive error, but not sex, had significant effects on the retinal layer thickness measurements at different locations (P < 0.05). The parafoveal and outer retinal layers were significantly thicker than the perifoveal and inner retina layers in all groups (P < 0.05). The full foveal thickness was higher and the full parafoveal and perifoveal regions were thinner in moderate to high myopic eyes than in the non-myopic eyes (P < 0.05), but were similar to those in the low myopic eyes (P > 0.05). The foveal thicknesses measured in the inner and outer layers of the retina were higher but the thicknesses measured at the inner and outer layers of the parafoveal and perifoveal regions were lower in moderate to high myopic eyes.


Conclusion: There were regional differences in the retinal layer thicknesses of healthy Saudi eyes, which was dependent on the central refractions. This is important when interpreting retinal nerve fiber layer thicknesses in myopia and disease management in Saudi participants.

Keywords:

Fovea, Myopia, Refractive error, Retina, Retinal Thickness, Saudi Arabia, Stratus Optical Coherence Tomography

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