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Nikkhah H, Feizi M, Abedi N, Karimi S, Yaseri M, Esfandiari H. Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy. JOVR [Internet]. 2020Feb.3 [cited 2024Apr.16];15(1):59–68. Available from: https://knepublishing.com/index.php/JOVR/article/view/5946

https://doi.org/10.18502/jovr.v15i1.5946

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authors

  • Homayoun Nikkhah

    Homayoun Nikkhah

    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Ophthalmology, Torfeh Hospital, Shahid Beheshti University of Medical Sciences
  • Mohadeseh Feizi

    Mohadeseh Feizi

    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Ophthalmology, Torfeh Hospital, Shahid Beheshti University of Medical Sciences
  • Naser Abedi

    Naser Abedi

    Department of Ophthalmology, Torfeh Hospital, Shahid Beheshti University of Medical Sciences
  • Saeed Karimi

    Saeed Karimi

    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Ophthalmology, Torfeh Hospital, Shahid Beheshti University of Medical Sciences
  • Mehdi Yaseri

    Mehdi Yaseri

    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Hamed Esfandiari

    Hamed Esfandiari

    Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USA

Published Date

  • Feb 3, 2020
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy

Journal of Ophthalmic and Vision Research (JOVR) / January–March 2020, Volume 15, Issue 1 / Pages 59–68

Abstract

Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls.


Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SDOCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500 μm from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared.


Results: The mean of PCT at 1000 μm was significantly thicker in NAION and fellow eyes compared to control eyes (169.7 ± 47, 154.4 ± 42.1, and 127.7 ± 49.9 μm, respectively, P < 0.001 and P = 0.42). The mean PCT at 1500 μm was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6 ± 52.8, 162.6 ± 46.1, and 135.1 ± 59 μm, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500 μm was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248).


Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology.

Keywords:

Choroidal Thickness, NAION, Non-arteritic Ischemic Optic Neuropathy, Optic Nerve Head, Swept Source AC-OCT

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