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Farvardin M, Reza Khalili M, Behnia M. Levodopa Plus Occlusion Therapy versus Occlusion Therapy Alone for Children with Anisometropic Amblyopia. JOVR [Internet]. 2019Oct.24 [cited 2024Jun.30];14(4):457-. Available from: https://knepublishing.com/index.php/JOVR/article/view/5451

https://doi.org/10.18502/jovr.v14i4.5451

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  • Cited by 4 articles

authors

  • Majid Farvardin

    Majid Farvardin

    Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
    https://orcid.org/0000-0001-9047-0329
  • Mohammad Reza Khalili

    Mohammad Reza Khalili

    Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mehdi Behnia

    Mehdi Behnia

    Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran

Published Date

  • Oct 24, 2019
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Levodopa Plus Occlusion Therapy versus Occlusion Therapy Alone for Children with Anisometropic Amblyopia

Journal of Ophthalmic and Vision Research (JOVR) / October–December 2019, Volume 14, Issue 4 / Pages 457– 464

Abstract

Purpose: This study aimed to compare the effects of short-term administration of levodopa plus occlusion therapy versus occlusion therapy alone in preschool children with hyperopic anisometropic amblyopia.


Methods: This comparative interventional study included 40 eligible preschool children aged 6 to 7 years with hyperopic anisometropic amblyopia. The primary outcome measure was the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity recorded at baseline, 3 weeks after the treatment initiation and 12 weeks after the treatment termination. The results were compared between the two groups.


Results: No statistically significant intergroup difference was observed in baseline logMAR visual acuities (P = 0.92). The mean logMAR visual acuities of the amblyopic eyes were significantly better in both groups three weeks after the treatment initiation than the baseline (P < 0.01 in both groups). At 12 weeks after treatment termination, the logMAR visual acuities of the amblyopic eyes were significantly better than the baseline values (P < 0.001 in the placebo group and P = 0.09 in the levodopa group). Intergroup comparisons revealed no statistically significant difference in visual acuities 3 weeks after the treatment initiation (P = 0.11) and 12 weeks after the treatment termination (P = 0.10). Twelve weeks after the treatment termination, visual acuities regressed 0.037 logMAR in the placebo group and 0.042 logMAR in the levodopa group. These regression rates were not significantly different (P = 0.89).


Conclusion: The results of this study provide evidence that adding short-term administration of levodopa to occlusion therapy in hyperopic anisometropic amblyopia offers no additional benefit in visual outcomes and provides no advantage in terms of the regression rate.

Keywords:

Amblyopia, Anisometropic, Levodopa, Occlusion Therapy

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