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Rahmani S, Rezaei Kanavi M, Ali Javadi M, Meskinfam Langroudi M, Afsar Aski S. Histopathologic Evaluation of Polymer Supports for Pintucci-Type Keratoprostheses: an Animal Study. JOVR [Internet]. 2019Jul.18 [cited 2024Apr.20];14(3):243–250. Available from: https://knepublishing.com/index.php/JOVR/article/view/4779

https://doi.org/10.18502/jovr.v14i3.4779

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authors

  • Saeed Rahmani

    Saeed Rahmani

    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mozhgan Rezaei Kanavi

    Mozhgan Rezaei Kanavi

    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mohammad Ali Javadi

    Mohammad Ali Javadi

    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Masoumeh Meskinfam Langroudi

    Masoumeh Meskinfam Langroudi

    Department of Chemistry, Lahijan Branch, Islamic Azad University, Lahijan, Iran
  • Sasha Afsar Aski

    Sasha Afsar Aski

    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Published Date

  • Jul 18, 2019
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Histopathologic Evaluation of Polymer Supports for Pintucci-Type Keratoprostheses: an Animal Study

Journal of Ophthalmic and Vision Research (JOVR) / July–September 2019, Volume 14, Issue 3 / Pages 243–250

Abstract

Purpose: To report histopathological findings for different types of polymers proposed as support for a Pintucci-type keratoprosthesis.


Methods: Six polymers, including three types of polyesters (#1-3), one type of polytetrafluoroethylene (PTFE, #4), polyethylene (#5), and expanded polytetrafluoroethylene (ePTFE, #6) were evaluated. Four samples of each material were placed under the orbicularis oculi muscles of 12 rabbits. After five weeks, the samples were removed and evaluated histopathologically. Fibrovascular tissue ingrowths were investigated in terms of tissue penetration depth into the materials (graded as none, mild, moderate, and intense) and fibrovascular ingrowth area at the ultimate level of tissue penetrance. ImageJ software was used to calculate fibrovascular tissue area between the material fibers, and the mean area values were compared between the materials.


Results: Polyester materials #1 and #3 demonstrated intense fibrovascular tissue penetration with a large fibrovascular ingrowth area; no overt tissue ingrowth was observed into material #6. The mean area of penetrated fibrovascular tissues was significantly different between materials (P < 0.001). Materials #2, #4, and #5 showed moderate fibrovascular tissue ingrowth and the area of presented fibrovascular tissue at the paracentral parts of material #4 was significantly smaller than that of materials #1 (P = 0.02) and #3 (P = 0.01).


Conclusion: Two polyester materials that had relatively large pore sizes demonstrated a deep and large area of fibrovascular ingrowth. Given that material #3 is thicker and more consistent than material #1, the former can be used as the appropriate material for supporting the Pintucci-type keratoprosthesis.

Keywords:

Fibrovascular Tissue Ingrowth; Keratoprosthesis; Pintucci; Polymer

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