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Kim D, Bautista S, Meer E, McGeehan B, Maguire M, Briceño C. Changes in Intraocular Pressure with Use of Periocular Triamcinolone Cream. JOVR [Internet]. 2022Aug.9 [cited 2024Jul.17];17(3):368–375. Available from: https://knepublishing.com/index.php/JOVR/article/view/11574

https://doi.org/10.18502/jovr.v17i3.11574

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authors

  • Diana Kim

    Diana Kim

    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA
  • Sana Bautista

    Sana Bautista

    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA
  • Elana Meer

    Elana Meer

    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • Brendan McGeehan

    Brendan McGeehan

    Center for Preventative Ophthalmology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
  • Maureen Maguire

    Maureen Maguire

    Center for Preventative Ophthalmology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
  • César Briceño

    César Briceño

    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA
    https://orcid.org/0000-0001-5301-0630

Published Date

  • Aug 9, 2022
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Changes in Intraocular Pressure with Use of Periocular Triamcinolone Cream

Journal of Ophthalmic and Vision Research (JOVR) / July–Sep 2022, Volume 17, Issue 3 / Pages 368–375

Abstract

Purpose: To evaluate the effect of periocular topical triamcinolone cream on intraocular pressure.


Methods: A retrospective chart review identified 57 patients, 114 eyes using triamcinolone cream (0.1%, 0.025%) with subsequent intraocular pressure (IOP) checks at three follow-up visits. Descriptive, univariate, and multivariate analyses were performed to assess effects of age, therapy duration, consecutive weeks on steroid, prescription strength, time of day, and method of measurement on IOP levels. Generalized Estimating Equations were used in regression models to account for correlation of eyes within subjects and across visits.


Results: We identified 57 patients using triamcinolone cream for allergic or eczematous dermatitis of the eyelid. Prescription strengths were 0.025% or 0.1% and patients were followed for a median of 4.9 months. Measurements of IOP at baseline did not change as compared to all IOP measurements at follow-ups and did not change with steroid strength. The mean change in IOP at all follow-up visits was 0.07 mm Hg (95% confidence interval [CI]: –0.36, 0.50). After adjustment for the method of tonometer and the patient’s age, the mean change was 0.03 mm Hg (95% CI: –0.68, 0.73, P = 0.93). Prescription strength and consecutive weeks of therapy were not associated with IOP. Two patients experienced a significant elevation in IOP of >10 mm Hg, one through the concomitant consequences of systemic corticosteroids usage and the other through prolonged topical application.


Conclusion: In patients taking periocular triamcinolone cream, there was no clinically meaningful change in mean IOP between baseline and follow-up visits, and IOP measurements were not related to variances in prescription strength or duration of therapy.

Keywords:

Glaucoma, Intraocular Pressure, Ocular Hypertension, Periocular Dermatitis, Steroids, Triamcinolone

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