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Hassanpour K, Mohammadi N, Sabbaghi H, Pakravan M. Peripapillary Capillary Network in Methanol Induced Optic Neuropathy. JOVR [Internet]. 2022Jan.21 [cited 2024Apr.26];17(1):140–145. Available from: https://knepublishing.com/index.php/JOVR/article/view/10180

https://doi.org/10.18502/jovr.v17i1.10180

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authors

  • Kiana Hassanpour

    Kiana Hassanpour

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Negin Mohammadi

    Negin Mohammadi

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Hamideh Sabbaghi

    Hamideh Sabbaghi

    Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mohammad Pakravan

    Mohammad Pakravan

    Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    https://orcid.org/0000-0002-9708-2916

Published Date

  • Jan 21, 2022
This journal is publishing all the articles under Creative Commons Attribution License CC BY 4.0.

Peripapillary Capillary Network in Methanol Induced Optic Neuropathy

Journal of Ophthalmic and Vision Research (JOVR) / January–March 2022, Volume 17, Issue 1 / Pages 140–145

Abstract

Purpose: To present the optical coherence tomography angiography (OCTA) findings of the radial peripapillary capillary (RPC) network in an individual with severe bilateral methanol-induced toxic optic neuropathy (MTON) in comparison to a normal subject and a patient with retinitis pigmentosa.


Case Report: A 35-year-old man with severe bilateral MTON was referred to the neuro-ophthalmology clinic at the Labbafinejad Medical Center. The Angio Vue OCT 3D set of 4.5 × 4.5 mm was used to measure the disc and peripapillary vessel density. Two subjects were examined with the same protocol as controls to determine the effect on the RPC vessel density in multiple scenarios. One of the controls was a healthy individual with the prerequisite matches of age and sex while the second one was a known retinitis pigmentosa (RP) patient. RPC density was measured as 37.7 in the patient with MTON, 46.9 in the RP patient, and 54.7 in the healthy control.


Conclusion: The reduction in the RPC vessel density in a patient with MTON compared to that of a healthy individual and also a patient with RP may be due to the loss of capillaries secondary to the loss of nerve fibers and ganglion cells. Moreover, MTON can be considered an optic neuropathy with direct mitochondrial damage to the endothelial cells of the capillaries.

Keywords:

Methanol-induced Toxic Optic Neuropathy, Optical Coherence Tomography Angiography, Radial Peripapillary Capillary Network

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