Peak Intraocular Pressure Time during Water Drinking Test and Its Relationship with Glaucoma Severity


Purpose: To investigate the association between the time of occurrence of intraocular pressure (IOP) peaks during the water-drinking test (WDT) and visual field damage in a cohort of primary open-angle glaucoma (POAG) patients.

Methods: In this retrospective, cross-sectional study, 98 eyes from 49 consecutive POAG patients were followed in a referral clinical practice. The relationship between the time when IOP peaks occurred during the WDT and the visual field mean deviation (MD) assessed with 24-2 visual field was tested with mixed-effects models.

Results: MD value was significantly associated with the time of IOP peak occurrence (P = 0.020) when adjusting for the number of medications, but not with the IOP peak values (P = 0.238).

Conclusion: The time of IOP peaks occurrence during the WDT was associated with glaucoma severity among treated POAG patients.


Glaucoma Severity, IOP Peak Time, Primary Open-angle Glaucoma, Water Drinking Test

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