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Mehmood, Z.-T.-N. H., & Papandreou, D. (2017). Vitamin D Supplementation does not Effect Adiposity in Healthy Adults. Arab Journal of Nutrition and Exercise (AJNE), 1(2), 101-112. https://doi.org/10.18502/ajne.v1i2.1227
https://doi.org/10.18502/ajne.v1i2.1227
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Zujaja-Tul-Noor Hamid Mehmood
Zujaja-Tul-Noor Hamid Mehmood
Department of Natural Sciences and Public Health, Zayed University, Abudhabi, UAE
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Dimitrios Papandreou
No author data available.
Published Date
- Nov 12, 2017
Vitamin D Supplementation does not Effect Adiposity in Healthy Adults
Abstract
Introduction: Vitamin D is crucial for skeletal and extraskeletal health outcomes as Vitamin D binding receptors are located through out body, and epidemiological data supports its link with many conditions. Data on vitamin D levels and especially Vitamin D supplementation in U.A.E. is essentially inadequate.
Design: Subjects (n=20) in this 1 month prospective study were given 2000 IU of daily Vitamin D without any special dietary or physical activity changes. Anthropometrics (weight, waist circumference, hip circumference), Vitamin D/ Calcium food frequency questionnaire and 24 –Hour recall were collected.
Results: Mean age of subjects was 28.7 years, and baseline mean serum Vitamin D level of 17.5 ng/mL ±6.47. It increased Vitamin D serum levels by a mean of 6.76 ng/mL. Hip Circumference also reduced statistically significantly by moderate 2% (p 0.03 ±0.59),
Conclusion: Vitamin D supplementation moderate dose daily can be pivotal in acquiring health benefits and reducing adiposity related factors. However, this surely calls for further investigation for longer period.
References
[1] C. B. Agborsangaya, E. Ngwakongnwi, M. Lahtinen, T. Cooke, and J. A. Johnson,“Multimorbidity prevalence in the general population: The role of obesity in chronic disease clustering,” BMC Public Health, vol. 13, pp. 1161–2458, 2013.
[2] F. Al Anouti, J. Thomas, L. Abdel-Wareth, J. Rajah, W. B. Grant, and A. Haq, “Vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates,” Dermato-Endocrinology, vol. 3, no. 4, pp. 235–239, 2011.
[3] F. Al Anouti, S. Al-Ameri, S. Thomas et al., “Sun avoidance among indoor employees leading to vitamin D deficiency and depression in the united arab emirates,” International Journal of Medicine and Medical Sciences, vol. 5, no. 11, pp. 503–509, 2013.
[4] L. Ceglia, J. Nelson, J. Ware et al., “Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program,” European Journal of Nutrition, vol. 56, no. 1, pp. 161–170, 2017.
[5] P. D. Chandler, L. Wang, X. Zhang et al., “Effect of vitamin D supplementation alone or with calcium on adiposity measures: A systematic review and meta-analysis of randomized controlled trials,” Nutrition Reviews, vol. 73, no. 9, pp. 577–593, 2015.
[6] L. S. Flor, M. R. Campos, A. F. Oliveira, and J. M. Schramm, Diabetes burden in brazil: Fraction attributable to overweight, obesity, and excess weight. Revista De Saude Publica, Schramm JM. Diabetes burden in brazil, Fraction attributable to overweight, 2015.
[7] J. C. Gallagher, M. Peacock, V. Yalamanchili, and L. M. Smith, “Effects of vitamin D supplementation in older African American women,” The Journal of Clinical Endocrinology & Metabolism, vol. 98, no. 3, pp. 1137–1146, 2013.
[8] A. Gangloff, J. Bergeron, E. Pelletier-Beaumont et al., “Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: Results from a 1-year lifestyle intervention in viscerally obese men,” International Journal of Obesity, vol. 39, no. 11, pp. 1638–1643, 2015.
[9] S. Kumar, N. Vasudeva, and S. Sharma, “GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats,” Cardiovascular Diabetology, vol. 11, no. 95, 2012.
[10] A. Hannemann, BH. Thuesen, N. Friedrich, H. Volzke, A. Steveling, and T. Ittermann, “Adiposity measures and vitamin D concentrations in northeast germany and denmark,” Nutrition Metabolism, vol. 2015; 12, pp. 24–015, 2015.
[11] M. F. Holick, “Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers,” Southern Medical Journal, vol. 98, no. 10, pp. 1024–1027, 2005.
[12] M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 7, pp. 1911–1930, 2011.
[13] M. F. Holick and T. C. Chen, “Vitamin D deficiency: a worldwide problem with health consequences,” American Journal of Clinical Nutrition, vol. 87, no. 4, pp. 1080S–1086S, 2008.
[14] Metrics and Evaluation. The State of US Health: Innovations, Insights, and Recommendations from the Global Burden of Disease Study, Institute for Health Metrics and Evaluation, Seattle, WA: IHME, 2013.
[15] Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, National Academies Press, Washington, D.C., 2011.
[16] K. Kearns, A. Dee, A. P. Fitzgerald, E. Doherty, and I. J. Perry, “Chronic disease burden associated with overweight and obesity in ireland: The effects of a small BMI reduction at population level,” BMC Public Health, vol. 14, pp. 143–2458, 2014.
[17] R. Kremer, P. P. Campbell, T. Reinhardt, and V. Gilsanz, “Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women,” The Journal of Clinical Endocrinology, vol. 94, no. 1, pp. 67–73, 2009.
[18] L. Marino and F. R. Jornayvaz, “Endocrine causes of nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 21, no. 39, pp. 11053–11076, 2015.
[19] H. Narchi, J. Kochiyil, S. Al Hamad, J. Yasin, L. Laleye, and A. Al Dhaheri, “Hypovitaminosis D in adolescent females - An analytical cohort study in the United Arab Emirates,” Paediatrics and International Child Health, vol. 35, no. 1, pp. 36–43, 2015.
[20] National Institute of Health, Losing Weight, Body Mass Index, 2016. Extracted form: http://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmi_dis.htm.
[21] C. H. O’Flanagan, L. W. Bowers, and S. D. Hursting, “A weighty problem: Metabolic perturbations and the obesity-cancer link,” in Hormone Molecular Biology and Clinical Investigation, vol. 23, pp. 47–57, Bowers LW Hursting SD. A weighty problem, Metabolic perturbations and the obesity-cancer link. Hormone Molecular Biology and Clinical Investigation, 2015.
[22] M. Pereira-Santos, P. R. Costa, A. M. Assis, C. A. Santos, and DB. Santos, “Obesity and vitamin D deficiency: A systematic review and meta-analysis,” in Proceedings of the Santos DB. Obesity and vitamin D deficiency: A systematic review and metaanalysis. Obesity Reviews : An Official Journal of the International Association for the
Study of Obesity, vol. 16, pp. 341–349.
[23] W. E. Plehwe, “Vitamin D deficiency in the 21st century: An unnecessary pandemic?” Clinical Endocrinology, vol. 59, no. 1, pp. 22–24, 2003.
[24] A. C. Ross, J. E. Manson, S. A. Abrams et al., “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 1, pp. 53–58, 2011.
[25] RE. Rusconi, V. De Cosmi, G. Gianluca, C. Giavoli, and C. Agostoni, “Vitamin D insufficiency in obese children and relation with lipid profile,” International Journal of Food Sciences and Nutrition, vol. 66, no. 2, pp. 132–134, 2015.
[26] J. W. Ryan, P. H. Anderson, and H. A. Morris, “Pleiotropic activities of vitamin D receptors - adequate activation for multiple health outcomes,” The Clinical Biochemist Reviews, vol. 36, no. 2, pp. 53–61, 2015.
[27] S. Shah, DM. Wilson, and LK. Bachrach, “Large doses of vitamin D fail to increase 25- hydroxyvitamin D levels or to alter cardiovascular risk factors in obese adolescents: A pilot study,” The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, pp. 19–23, 2015.
[28] S. B. Sridhar, P. G. Rao, S. K. Multani, and M. Jain, “Assessment of prevalence of hypovitaminosis D in multiethnic population of the united arab emirates,” Journal of Advanced Pharmaceutical Technology & Research, vol. 7, no. 2, pp. 48–53, 2016.
[29] K. S. Vimaleswaran, D. J. Berry, C. Lu, E. Tikkanen, S. Pilz, and L. T. Hiraki, “Causal relationship between obesity and vitamin D status: Bi-directional mendelianrandomization analysis of multiple cohorts,” PLoS Medicine, vol. 10, no. 2, pp. 1–13,2013.
[30] World Health Organization, Waist circumference and waist-hip ratio : report of a WHO expert consultation, Geneva, 8-11 December 2008. Geneva : World Health Organization; 2011. Available from: http://www.who.int/iris/handle/10665/44583.
[31] World Health Organization, Overweight and Obesity, 2016. Extracted from:
http://www.who.int/mediacentre/factsheets/fs311/en.
[2] F. Al Anouti, J. Thomas, L. Abdel-Wareth, J. Rajah, W. B. Grant, and A. Haq, “Vitamin D deficiency and sun avoidance among university students at Abu Dhabi, United Arab Emirates,” Dermato-Endocrinology, vol. 3, no. 4, pp. 235–239, 2011.
[3] F. Al Anouti, S. Al-Ameri, S. Thomas et al., “Sun avoidance among indoor employees leading to vitamin D deficiency and depression in the united arab emirates,” International Journal of Medicine and Medical Sciences, vol. 5, no. 11, pp. 503–509, 2013.
[4] L. Ceglia, J. Nelson, J. Ware et al., “Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program,” European Journal of Nutrition, vol. 56, no. 1, pp. 161–170, 2017.
[5] P. D. Chandler, L. Wang, X. Zhang et al., “Effect of vitamin D supplementation alone or with calcium on adiposity measures: A systematic review and meta-analysis of randomized controlled trials,” Nutrition Reviews, vol. 73, no. 9, pp. 577–593, 2015.
[6] L. S. Flor, M. R. Campos, A. F. Oliveira, and J. M. Schramm, Diabetes burden in brazil: Fraction attributable to overweight, obesity, and excess weight. Revista De Saude Publica, Schramm JM. Diabetes burden in brazil, Fraction attributable to overweight, 2015.
[7] J. C. Gallagher, M. Peacock, V. Yalamanchili, and L. M. Smith, “Effects of vitamin D supplementation in older African American women,” The Journal of Clinical Endocrinology & Metabolism, vol. 98, no. 3, pp. 1137–1146, 2013.
[8] A. Gangloff, J. Bergeron, E. Pelletier-Beaumont et al., “Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: Results from a 1-year lifestyle intervention in viscerally obese men,” International Journal of Obesity, vol. 39, no. 11, pp. 1638–1643, 2015.
[9] S. Kumar, N. Vasudeva, and S. Sharma, “GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats,” Cardiovascular Diabetology, vol. 11, no. 95, 2012.
[10] A. Hannemann, BH. Thuesen, N. Friedrich, H. Volzke, A. Steveling, and T. Ittermann, “Adiposity measures and vitamin D concentrations in northeast germany and denmark,” Nutrition Metabolism, vol. 2015; 12, pp. 24–015, 2015.
[11] M. F. Holick, “Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers,” Southern Medical Journal, vol. 98, no. 10, pp. 1024–1027, 2005.
[12] M. F. Holick, N. C. Binkley, H. A. Bischoff-Ferrari et al., “Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 7, pp. 1911–1930, 2011.
[13] M. F. Holick and T. C. Chen, “Vitamin D deficiency: a worldwide problem with health consequences,” American Journal of Clinical Nutrition, vol. 87, no. 4, pp. 1080S–1086S, 2008.
[14] Metrics and Evaluation. The State of US Health: Innovations, Insights, and Recommendations from the Global Burden of Disease Study, Institute for Health Metrics and Evaluation, Seattle, WA: IHME, 2013.
[15] Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, National Academies Press, Washington, D.C., 2011.
[16] K. Kearns, A. Dee, A. P. Fitzgerald, E. Doherty, and I. J. Perry, “Chronic disease burden associated with overweight and obesity in ireland: The effects of a small BMI reduction at population level,” BMC Public Health, vol. 14, pp. 143–2458, 2014.
[17] R. Kremer, P. P. Campbell, T. Reinhardt, and V. Gilsanz, “Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women,” The Journal of Clinical Endocrinology, vol. 94, no. 1, pp. 67–73, 2009.
[18] L. Marino and F. R. Jornayvaz, “Endocrine causes of nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 21, no. 39, pp. 11053–11076, 2015.
[19] H. Narchi, J. Kochiyil, S. Al Hamad, J. Yasin, L. Laleye, and A. Al Dhaheri, “Hypovitaminosis D in adolescent females - An analytical cohort study in the United Arab Emirates,” Paediatrics and International Child Health, vol. 35, no. 1, pp. 36–43, 2015.
[20] National Institute of Health, Losing Weight, Body Mass Index, 2016. Extracted form: http://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmi_dis.htm.
[21] C. H. O’Flanagan, L. W. Bowers, and S. D. Hursting, “A weighty problem: Metabolic perturbations and the obesity-cancer link,” in Hormone Molecular Biology and Clinical Investigation, vol. 23, pp. 47–57, Bowers LW Hursting SD. A weighty problem, Metabolic perturbations and the obesity-cancer link. Hormone Molecular Biology and Clinical Investigation, 2015.
[22] M. Pereira-Santos, P. R. Costa, A. M. Assis, C. A. Santos, and DB. Santos, “Obesity and vitamin D deficiency: A systematic review and meta-analysis,” in Proceedings of the Santos DB. Obesity and vitamin D deficiency: A systematic review and metaanalysis. Obesity Reviews : An Official Journal of the International Association for the
Study of Obesity, vol. 16, pp. 341–349.
[23] W. E. Plehwe, “Vitamin D deficiency in the 21st century: An unnecessary pandemic?” Clinical Endocrinology, vol. 59, no. 1, pp. 22–24, 2003.
[24] A. C. Ross, J. E. Manson, S. A. Abrams et al., “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know,” The Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 1, pp. 53–58, 2011.
[25] RE. Rusconi, V. De Cosmi, G. Gianluca, C. Giavoli, and C. Agostoni, “Vitamin D insufficiency in obese children and relation with lipid profile,” International Journal of Food Sciences and Nutrition, vol. 66, no. 2, pp. 132–134, 2015.
[26] J. W. Ryan, P. H. Anderson, and H. A. Morris, “Pleiotropic activities of vitamin D receptors - adequate activation for multiple health outcomes,” The Clinical Biochemist Reviews, vol. 36, no. 2, pp. 53–61, 2015.
[27] S. Shah, DM. Wilson, and LK. Bachrach, “Large doses of vitamin D fail to increase 25- hydroxyvitamin D levels or to alter cardiovascular risk factors in obese adolescents: A pilot study,” The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, pp. 19–23, 2015.
[28] S. B. Sridhar, P. G. Rao, S. K. Multani, and M. Jain, “Assessment of prevalence of hypovitaminosis D in multiethnic population of the united arab emirates,” Journal of Advanced Pharmaceutical Technology & Research, vol. 7, no. 2, pp. 48–53, 2016.
[29] K. S. Vimaleswaran, D. J. Berry, C. Lu, E. Tikkanen, S. Pilz, and L. T. Hiraki, “Causal relationship between obesity and vitamin D status: Bi-directional mendelianrandomization analysis of multiple cohorts,” PLoS Medicine, vol. 10, no. 2, pp. 1–13,2013.
[30] World Health Organization, Waist circumference and waist-hip ratio : report of a WHO expert consultation, Geneva, 8-11 December 2008. Geneva : World Health Organization; 2011. Available from: http://www.who.int/iris/handle/10665/44583.
[31] World Health Organization, Overweight and Obesity, 2016. Extracted from:
http://www.who.int/mediacentre/factsheets/fs311/en.