@article{Babakhanzadeh_Danaei_Abedinzadeh_Reza Ashrafzadeh_Ghasemi_2021, title={Association of miR-146a and miR196a2 genotype with susceptibility to idiopathic recurrent pregnancy loss in Iranian women: A case-control study}, volume={19}, url={https://knepublishing.com/index.php/ijrm/article/view/9620}, DOI={10.18502/ijrm.v19i8.9620}, abstractNote={<p><strong>Background:</strong> Recurrent pregnancy loss (RPL) is the most common complaint of pregnancy in females with a prevalence of 5%. Numerous documents have shown that single nucleotide polymorphisms are able to change miRNA transcription and/or maturation, which may alter the incidence of disorders such as RPL.</p> <p><strong>Objective:</strong> To assess the relationship of miR-146aC &gt; G (rs2910164) and miR-196a2T &gt; C (rs11614913) with RPL susceptibility in Iranian women.</p> <p><strong>Materials and Methods:</strong> Blood samples were collected from 214 women who had experienced at least two consecutive spontaneous miscarriages (case) and 147 normal individuals without a history of miscarriage (control). MiR-146aC &gt; G and miR-196a2T &gt; C genotypes were evaluated via the restriction fragment length polymorphism technique.</p> <p><strong>Results:</strong> The genotypes incidence did not show a significant difference in pre-miR-146aC &gt; G polymorphism CC vs CG + GG (p = 0.854; OR = 0.933; 95% CI) and CC + CG vs GG (p = 0.282; OR = 1.454; 95% CI). Also, no significant difference was observed between pre-miR-196a2T &gt; C polymorphism TT vs TC + CC (p = 0.862; OR = 0.938; 95% CI) and TT + TC vs CC and (p = 0.291; OR = 1.462; 95% CI) in both the case and control groups.</p> <p><strong>Conclusion:</strong> The results showed that although the distribution of miR-146aC &gt; G and miR-196a2T &gt; C was different between the unknown RPL and control groups, these variances were not statistically significant.</p> <p><em><strong>Key words:</strong> RPL, miR-146a, miR196a2, Polymorphism, RFLP.</em></p&gt;}, number={8}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Babakhanzadeh, Emad and Danaei, Hamid and Abedinzadeh, Mohammad and Reza Ashrafzadeh, Hamid and Ghasemi, Nasrin}, year={2021}, month={Sep.}, pages={725-732} }