@article{Namavar Jahromi_Borzou_Ebrahim Parsanezhad_Anvar_Ghaemmaghami_Sabetian_2021, title={Associations of insulin resistance, sex hormone-binding globulin, triglyceride, and hormonal profiles in polycystic ovary syndrome: A cross-sectional study}, volume={19}, url={https://knepublishing.com/index.php/ijrm/article/view/9476}, DOI={10.18502/ijrm.v19i7.9476}, abstractNote={<p><strong>Background:</strong> Insulin resistance (IR) occurs in 50–70% of women with polycystic ovary syndrome (PCOS) and can be applied as a prediabetic feature in PCOS.</p> <p><strong>Objective:</strong> In this study, indirect methods including fasting blood sugar (FBS), fasting insulin (FI), FBS/FI ratio, and quantitative insulin sensitivity check index (QUICKI) were compared with the homeostasis model assessment of insulin resistance (HOMA-IR) as a standard technique. The association of IR to sex hormone-binding globulin (SHBG) and several hormones was also analyzed.</p> <p><strong>Materials and Methods:</strong> This cross-sectional study was performed on 74 PCOS women. Sensitivity and specificity of each IR method was calculated based on HOMA-IR. Hormonal profiles of the patients were compared between the groups with defined normal and abnormal values of IR.</p> <p><strong>Results:</strong> Triglyceride levels had a positive association with FBS and HOMA-IR (p = 0.002 and p = 0.01, respectively) with a negative association to QUICKI and SHBG (p = 0.02 and p = 0.02, respectively). SHBG showed a significant negative association with FBS (p = 0.001). Dehydroepiandrosterone sulfate showed a positive association with FI (p = 0.002). Seven PCOS women showed abnormal SHBG levels (&lt; 36 nmol/L) while expressed normal values of the rest of the studied variables. FI and QUICKI had the highest sensitivity while FBS/FI and QUICKI had the highest specificity when HOMA-IR was applied as a standard test.</p> <p><strong>Conclusion:</strong> SHBG and triglyceride had a significant negative and positive association with IR, respectively. HOMA-IR followed by FI and QUICKI is the most sensitive test for the detection of IR. SHBG levels can be a helpful biomarker for the diagnosis of PCOS.</p> <p><em><strong>Key words:</strong> Polycystic ovary syndrome, Insulin resistance, Sex hormone-binding globulin.</em></p&gt;}, number={7}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Namavar Jahromi, Bahia and Borzou, Niloofar and Ebrahim Parsanezhad, Mohammad and Anvar, Zahra and Ghaemmaghami, Parvin and Sabetian, Soudabeh}, year={2021}, month={Aug.}, pages={653–662} }