@article{Khazaei_Ghanbari_Khazaei_2021, title={Improved hormonal and oxidative changes by Royal Jelly in the rat model of PCOS: An experimental study}, volume={19}, url={https://knepublishing.com/index.php/ijrm/article/view/9373}, DOI={10.18502/ijrm.v19i6.9373}, abstractNote={<p><strong>Background:</strong> Polycystic ovarian syndrome (PCOS) is an endocrine and complex metabolic disorder, associated with anovulation, changes in sex hormone, biochemical factors, and ovarian tissue. Royal Jelly (RJ) has antioxidant and anti-inflammatory properties.</p> <p><strong>Objective:</strong> To examine the therapeutic effect of RJ on PCOS-related hormonal and biochemical changes in a rat model of PCOS.</p> <p><strong>Materials and Methods:</strong> In this experimental study, 42 female Wistar rats (weighing 180–200 gr, aged 10–12 wk) were divided into six groups (n = 7/each): control; PCOS; RJ 100 mg/kg; RJ 200 mg/kg; PCOS + RJ 100 mg/kg; and PCOS + RJ 200 mg/kg. After 21 days, the animals were weighed and dissected. The serums were used for nitric oxide (NO) and ferric-reducing antioxidant power (FRAP) assay and estradiol and progesterone measurements. The ovaries were assessed for histological changes.</p> <p><strong>Results:</strong> PCOS increased estradiol and NO levels, and decreased progesterone and FRAP levels. In PCOS + RJ groups, the progesterone (p = 0.01) and FRAP levels (p ≤ 0.001) increased and the estradiol and NO (p ≤ 0.001) levels decreased significantly. Moreover, the number of mature follicles (p = 0.01) and corpus luteum increased (p ≤ 0.001), and ovarian and uterus weight deceased significantly (p ≤ 0.001).</p> <p><strong>Conclusion:</strong> RJ improved estradiol, progesterone, FRAP, and NO levels, and ovarian structure in the rat model of PCOS.</p> <p><em><strong>Key words:</strong> Royal Jelly, Polycystic ovary syndrome, Ovary, Sex hormone.</em></p&gt;}, number={6}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Khazaei, Fatemeh and Ghanbari, Elham and Khazaei, Mozafar}, year={2021}, month={Jul.}, pages={515–524} }