@article{Eftekhar_Saeed_2020, title={Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT Running}, volume={13}, url={https://knepublishing.com/index.php/ijrm/article/view/6891}, DOI={10.18502/ijrm.v13i4.6891}, abstractNote={<p><strong>Background:</strong> Aromatase inhibitors prevent the aromatization of androgens into estrogens, which reduces the negative feedback of estrogen on the hypothalamicpituitary axis. It is clear that increasing the secretion of follicle-stimulating hormones results in an increased follicular growth.</p> <p><strong>Objective:</strong> This study aimed to evaluate the effect of adding letrozole to gonadotropin on in vitro fertilization outcomes in normal responders.</p> <p><strong>Materials and Methods:</strong> In this randomized clinical trial, 100 normal responder women candidate for controlled ovarian stimulation were randomly enrolled in two groups (n = 50/each). In the case group letrozole was added to gonadotropin in the antagonist protocol. The control group received the conventional antagonist protocol. The main outcome was clinical and chemical pregnancy; and the second outcomes were the number of mature oocytes, the fertilization rate, estradiol level, and the total dose of gonadotropins.</p> <p><strong>Results:</strong> Basic clinical and demographic features were comparable between the groups. Estradiol level on the day of human-chorionic-gonadotropin administration and the total gonadotropin consumption were significantly higher in the control group than the case group (p = 0.045). In addition, the number of MII oocytes was higher (but not significantl) in the case group than the control group (p = 0.09). Moreover, the endometrial thickness was significantly lower in the case group. There were no significant differences in fertilization rate and chemical and clinical pregnancy rates between the two groups.</p> <p><strong>Conclusion:</strong> Although adding letrozole to gonadotropin in normal responders reduces the total dose of gonadotropin, it does not improve the pregnancy outcomes.</p> <p><em><strong>Key words:</strong> Letrozole, Ovarian stimulation, Pregnancy.</em></p&gt;}, number={4}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Eftekhar, Maryam and Saeed, Lida}, year={2020}, month={May}, pages={287–294} }