@article{Azizi_Soleimani Mehranjani_2019, title={The effect of green tea extract on the sperm parameters and histological changes of testis in rats exposed to para-nonylphenol}, volume={17}, url={https://knepublishing.com/index.php/ijrm/article/view/5290}, DOI={10.18502/ijrm.v17i10.5290}, abstractNote={<p><strong>Background:</strong> Para-nonylphenol (p-NP), an environmental contaminant, can generate free radicals that disturbs the reproductive properties. Green tea extract (GTE) is an antioxidant which may prevent the adverse effects of free radicals.</p> <p><strong>Objective:</strong> The aim was to investigate the effect of GTE on sperm parameters and testis tissue in p-NP-treated rats.</p> <p><strong>Materials and Methods:</strong> 24 adult male Wistar rats (215 ± 20 gr) were randomly divided into four groups (n = 6/each) – including control, p-NP (200 mg/kg/day), GTE (200 mg/kg/day), and p-NP + GTE – and orally treated for 56 days. The right testes and left caudal epididymis were used to evaluate selected parameters. In addition, the concentration of serum malondialdehyde was calculated.</p> <p><strong>Results:</strong> A significant decrease in the sperm number, motility, viability and morphology (p &lt; 0.001) was observed in the rats treated with p-NP compared to the control ones. The diameter of seminiferous tubules (p &lt; 0.001), thickness of germinal epithelium (p = 0.018), total volume of testis (p = 0.009), volume of seminiferous tubules (p &lt; 0.001), and testis weight (p = 0.017) decreased in the p-NP group in contrast with the other groups. Moreover, a significant increase of the malondialdehyde concentration was seen in the p-NP group when compared with the controls (p = 0.043). The majority of adverse effects of p-NP could be recovered following the administration of GTE.</p> <p><strong>Conclusion:</strong> It seems GTE can be used as a potent antioxidant in the case of p-NP toxication.</p> <p><em><strong>Key words:</strong> Green tea extract, Para-nonylphenol, Sperm, Testis, Rat.</em></p&gt;}, number={10}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Azizi, Parisa and Soleimani Mehranjani, Malek}, year={2019}, month={Oct.} }