@article{Nataj Majd_Moini_Samimi Sadeh_Bastanhagh_2023, title={The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial}, volume={20}, url={https://knepublishing.com/index.php/ijrm/article/view/12562}, DOI={10.18502/ijrm.v20i12.12562}, abstractNote={<p><strong>Background:</strong> Endometrial receptivity is crucial for embryo implantation, and excessive uterine contraction reduces success. Nifedipine which is a calcium channel blocker, could decrease uterine contraction and improve pregnancy outcomes.</p> <p><strong>Objective:</strong> This study aimed to assess the effect of Nifedipine before embryo transfer on the pregnancy outcome in women undergoing in vitro fertilization (IVF) in a tertiary center in Iran.</p> <p><strong>Materials and Methods:</strong> 150 women who were candidates for IVF were randomly assigned into 2 groups: group 1 received 20 mg Nifedipine 30 min before embryo transfer, and group 2 received no intervention. Blood pressure of the participants was monitored every 10 min for 1 hr under the supervision of an anesthesiologist. Finally, implantation rate and chemical and clinical pregnancy rates were compared between groups.</p> <p><strong>Results:</strong> At the end of the study, 140 participants were included in the final analyses. No significant difference was observed in clinical pregnancy rates between groups (20% vs. 22%, p = 0.51)</p> <p><strong>Conclusion:</strong> Nifedipine administration before embryo transfer does not improve the implantation and clinical pregnancy rates in women undergoing IVF.</p> <p><strong>Key words:</strong> Nifedipine, In vitro fertilization, Uterus, Contraction.</p&gt;}, number={12}, journal={International Journal of Reproductive BioMedicine (IJRM)}, author={Nataj Majd, Masoomeh and Moini, Ashraf and Samimi Sadeh, Saghar and Bastanhagh, Ehsan}, year={2023}, month={Jan.}, pages={1013–1018} }