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Bagheri, R. B., Bazrafkan, M., Sabour, A., Ataei, M., Badehnoosh, B., Mashak, B., Khakifirooz, B., & Moghaddam, R. (2023). The comparison of pregnancy outcomes in fresh and frozen embryo transfer: A cross- sectional study. International Journal of Reproductive BioMedicine (IJRM), 21(7), 551–556. https://doi.org/10.18502/ijrm.v21i7.13891

https://doi.org/10.18502/ijrm.v21i7.13891

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authors

  • Ramesh Baradaran Bagheri

    Ramesh Baradaran Bagheri

    Department of Obstetrics and Gynecology, Alborz University of Medical Sciences, Karaj, Iran.
  • Mahshid Bazrafkan

    Mahshid Bazrafkan

    Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
  • Abbas Sabour

    Abbas Sabour

    Alborz University of Medical Sciences, Karaj, Iran.
  • Mina Ataei

    Mina Ataei

    Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
  • Bita Badehnoosh

    Bita Badehnoosh

    Department of Obstetrics and Gynecology, Dietary Supplements and Probiotics Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Banafsheh Mashak

    Banafsheh Mashak

    School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
  • Bahareh Khakifirooz

    Bahareh Khakifirooz

    Department of Obstetrics and Gynecology, School of Medicine, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
  • Ramin Moghaddam

    Ramin Moghaddam

    International Academy of Health Sciences Informatics (IAHSI), Geneva, Switzerland.

Published Date

  • Aug 19, 2023

The comparison of pregnancy outcomes in fresh and frozen embryo transfer: A cross- sectional study

International Journal of Reproductive BioMedicine (IJRM) / International Journal of Reproductive BioMedicine (IJRM): Volume 21, Issue No. 7 / Pages 551–556

Abstract

Background: The benefits of frozen embryo transfer (FET) vs. fresh embryo transfer for in vitro fertilization (IVF) have been discussed in previous studies.


Objective: To determine and compare the pregnancy outcomes following FET and frozen embryo transfer in women who underwent assisted reproductive techniques.


Materials and Methods: In this cross-sectional study, 233 women candidates for IVF/intra cytoplasmic sperm injection who referred to the Kamali Training Medical Center, Karaj, Iran during 2019-2020 were evaluated in 2 groups of fresh (n = 127) and frozen (n = 106) embryo transfers. The rates of pregnancy outcomes including chemical and clinical pregnancy, live birth, preeclampsia, ectopic pregnancy, still birth, and pregnancy loss were compared between groups in 3 age subgroups (< 25, 25-35, and 35-40 yr old).


Results: No significant difference in terms of chemical and clinical pregnancy and live birth rates were observed between groups in women aged < 25 yr. Chemical and clinical pregnancy and live birth rates were significantly higher in the FET group compared to fresh group in 25-35-yr-old women (p = 0.01, p = 0.03, and p = 0.01, respectively). In 35-40-yr-old women, no significant differences were observed in terms of chemical and clinical pregnancy rates, but live birth rate was found to be significantly higher in the FET group (p = 0.02). The pregnancy loss was lower in the FET group (p = 0.038).


Conclusion: In conclusion, the FET method in women aged 25-35 yr significantly increases the chance of successful IVF/intra cytoplasmic sperm injection.


Key words: Assisted reproductive techniques, In vitro fertilization, Embryo transfer, Cryopreservation, Outcome assessment. 

References
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