TY - JOUR AU - Imad Fadl-Elmula AU - Rania Giha AU - Sawsan AH Deaf AU - Lamyaa Ahmed El Hassan AU - Ahmed M. Hassan AU - Mohamed AR Arbab PY - 2017/09/06 Y2 - 2024/03/28 TI - Rare Suprasellar Chordoid Meningioma with INI1 Gene Mutation JF - Sudan Journal of Medical Sciences (SJMS) JA - Sudan JMS VL - 12 IS - 3 SE - Original Research Article DO - 10.18502/sjms.v12i3.1001 UR - https://knepublishing.com/index.php/SJMS/article/view/1001 AB - Background: Chordoid Meningioma is a rare brain tumour characterized genetically by loss of genetic material from chromosome 22q at cytogenetic level resulting in mutation of NF2 gene.Objectives and case report: In the present report, we described a rare case of suprasellar chordoid meningioma, which presented in a 32-year-old-woman. Her only complain was throbbing headache. Neurological examination showed left temporal hemianopia, decreased visual acuity (3/6), and no physical abnormalities related to Castleman syndrome were noted. Cranial magnetic resonance (MR) images demonstrated a 28x15 mm mass in the sellar region, which showed iso-to low intensity that enhanced vividly after gadolinium with upwards displacement of the Optic chiasm.Total surgical excision of the tumour was performed and subsequent histological examination of the tumour showed typical histology pattern of chordoid meningioma grade II according to the WHO classification system of meningiomas.Genomic DNA was extracted and mutation analysis for INI1 gene using primer of exon 4, 5, 7, and 9 showed mutation involving exon 9. DNA sequencing showedheterozygosity C­­­­­­­­­­­­­­­­­­-T mutation in exon 9 of INI1 gene leading to change of amino acid serine to phenylalanine at (codon 63). The details of this case are presented with a review of the literature. ER -