@article{Varim_Gokosmanoglu_Oztop_2020, title={Clinical Evaluation on Non-Functional Invasive Hypophysis Adenomas}, volume={15}, url={https://knepublishing.com/index.php/SJMS/article/view/5027}, DOI={10.18502/sjms.v15i2.5027}, abstractNote={<p><strong>Background</strong></p> <p>There are ongoing studies to predetermine non-functional invasive pituitary adenomas which may show aggressive behavior. Our aim is to discuss whether there is a relationship between the immunohistochemical presence of GH, FSH, LH, PRL, ACTH, TSH and their aggressive clinical course in non-functional pituitary adenomas.</p> <p><strong>Materials and Methods </strong></p> <p>In this study, we evaluated retrospectively the files of the patients who were diagnosed with thesellar or parasellar tumor in our endocrinology clinic between the years of 2004-2014.The patients were divided into two groups as non-invasive pituitary adenomas and non-functional invasive pituitary adenomas. The immunohistochemical staining characteristics were compared between the two groups.</p> <p><strong>Results </strong></p> <p>In this study, we scanned the data of 70 patients who were followed for non-functional sellar or parasellar mass. 47.1% of the patients were female and 52.9% of the patients were male.39 patients had a non-functional pituitary adenoma.The rate of non-functional invasive adenoma was found to be 20.5%. There was a significant relationship between the immunohistochemical positivity of GH, FSH, LH andaggressive behavior of non-functional invasive adenomas. There was no a significant relationship between the immunohistochemicalpositivityof PRL, ACTH, TSH and aggressive behavior of non-functional invasive adenomas.</p> <p><strong>Conclusion </strong></p> <p>We found silent GH and gonadotropin adenomas as non-functional aggressive pituitary adenoma. More aggressive treatment and close clinical monitoring should be performed because atypical pituitary adenomas are characterized by invasive growth and aggressive clinical course.</p&gt;}, number={2}, journal={Sudan Journal of Medical Sciences (SJMS)}, author={Varim, Ceyhun and Gokosmanoglu, Feyzi and Oztop, Kenan Evren}, year={2020}, month={Jun.}, pages={106–113} }