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Santoso, B. B., Hernandez, H. P., Rodriguez, E. B., & Dalmacio, I. F. (2017). Two Antibacterial Compounds: Velutin and 4- (Hydroxy (Oxiran-2-yl)Methyl)-2-Methoxyphenol from the Stem Bark of Drimys arfakensis Gibbs. KnE Life Sciences, 3(5), 51-62. https://doi.org/10.18502/kls.v3i5.978

https://doi.org/10.18502/kls.v3i5.978

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authors

  • Bimo Budi Santoso

    Bimo Budi Santoso

    Department of Chemistry, Faculty Mathematics and Natural Sciences, University of Papua, Jl. Gunung Salju Amban, Manokwari 98314, Indonesia
  • Hidelisa Padua Hernandez
    No author data available.
  • Evelyn B Rodriguez
    No author data available.
  • Ida Farida Dalmacio
    No author data available.

Published Date

  • Sep 11, 2017

Two Antibacterial Compounds: Velutin and 4- (Hydroxy (Oxiran-2-yl)Methyl)-2-Methoxyphenol from the Stem Bark of Drimys arfakensis Gibbs.

KnE Life Sciences / International Conference on Natural Resources and Life Sciences (NRLS-2016) / Pages 51-62

Abstract

Antimicrobial-guided fractionation and isolation of the bioactive compounds from the stem bark of Drimys arfakensis Gibbs. were carried out. Two antibacterial compounds were isolated. The sructures of the antibacterial compounds were elucidated by spectroscopic methods such as 1H NMR, 13C NMR, 2-D NMR, ESI-MS and EI-MS. Based on the spectroscopic data, the two antibacterial compounds were velutin, 1 and  4-(hydroxyl(oxiran-2-yl)methyl)-2-methoxyphenol, 2. Compound 1 exhibited low activity against methicillin-resistant Staphylococcus aureus (MRSA) (B-1823) with MIC value of 250 µg · mL–1, while compound 2 possesses strong activity against S. aureus (MRSA) (B-1823) with MIC value of 15.60 µg · mL–1.No activity of both compounds against Escherichia coli (B-1634) and Candida albicans (B-2219) was observed.

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