The Association Between Serum Resistin Level with the Degree of Coronary Artery Stenosis
Abstract
Coronary artery stenosis is a thickening of intimal coronary artery due to chronic inflammation of blood vessels, characterized by the accumulation of inflammatory cells, vascular smooth muscle cells, lipid, and fibrotic tissue. Resistin, a cysteine-rich secretory protein, produced by monocytes and adipose cells, increases proinflammatory cytokines. This study was conducted to analyze the association between serum resistin level with the severity of coronary artery stenosis. This cross-sectional study was performed in 60 patients aged 30-70 years old who were suspected to have coronary heart disease (CHD) and underwent coronary angiography at Cardiology Department of Dr. Moewardi Hospital in Surakarta. The cutoff point of serum resistin level was
determined by receiver operating curve (ROC). The data were analyzed to determine the prevalence ratio of each variable, followed by logistic regression, p<0.05 was considered statistically significant. This study found a significant association between serum resistin level and the severity of coronary artery stenosis. At the cutoff point of 6.37 ng/ml, bivariate and multivariate analysis showed that resistin had the prevalence ratio (PR) of 6.56 (95% CI: 1.705-25.263; p = 0.005) and 7.47 (95% CI: 1.562-35.784; p = 0.012), respectively. Even after adjustment with body mass index, sex, hypertension, dyslipidemia and type 2 DM, resistin showed significant association with the severity of coronary artery stenosis (PR: 7.48; 95% CI: 1.562-35.784; p = 0,012).
Keywords: coronary artery stenosis, resistin
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