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Laqif, A., Aini Fatah, N., & Hari Respati, S. (2019). Effectiveness of Platelet Rich Fibrin (PRF) Compared with Conventional Therapy Toward Wound Dehiscence of Post-Operative Laparotomy. KnE Life Sciences, 4(12), 177–184. https://doi.org/10.18502/kls.v4i12.4172

https://doi.org/10.18502/kls.v4i12.4172

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authors

  • A Laqif
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  • N Aini Fatah
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  • S Hari Respati
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Published Date

  • Mar 25, 2019

Effectiveness of Platelet Rich Fibrin (PRF) Compared with Conventional Therapy Toward Wound Dehiscence of Post-Operative Laparotomy

KnE Life Sciences / The 1st International Conference on Health, Technology and Life Sciences (ICO-HELICS) / Pages 177–184

Abstract

Objective: To compare the effectiveness of Platelet Rich Fibrin (PRF) and conventional therapy toward wound dehiscence of post-operative laparotomy in the Department of Obstetrics and Gynecology at Moewardi hospital.



Methods: This was a cross-sectional study conducted from September to December 2017 on obstetrics and gynecology post-laparotomy patients undergoing subtotal wound dehiscence in the Department of Obstetrics and Gynecology at Moewardi hospital from 2013 to 2017. They were divided into 2 groups, group 1 consisted of patients with subtotal wound dehiscence after obstetric and gynecological operation receiving conventional non-operative therapy, and group 2 was those having subtotal wound dehiscence after obstetrics and the gynecological operation receiving non-operative treatment with PRF. The data were analyzed using the T-test, performed by SPSS (Software Package for Social Science).



Results: There were 15 subjects in each group meeting the inclusion and exclusion criteria for both case and control groups. The statistical test showed that the average duration of wound healing in control group (12.60 about 2.58) was longer than in PRF group (7.0 about 3.52) with the significance of value p= 0.001 (p<0.05). The PRF group spent less cost (IDR 4.511.362 ± 2.977.934) compared with the conventional therapy group (IDR 12.540.735 ± 8.227.433) with p = 0.001 (p<0.05). Conclusions: Patients with PRF therapy had faster-wound healing duration, and the result was statistically significant with p=0.001 (p<0.05). PRF therapy also had more
cost-effectiveness compared with conventional therapy with p=0.001(p<0.05).



Keywords: Wound healing, Platelet-rich fibrin

References
[1] Ramneesh, G., Sheerin, S., Surinder, S., & Bir, S. A prospective study of predictors for post laparotomy abdominal wound dehiscence. Journal of Clinical and Diagnostic Research: JCDR, 2014: 8(1), 80–3.


[2] Alavi, S., Malek, F., Eshghi, P, Arzhangian, H. Autologous platelet-rich plasma for the healing of an oncologic dehisced wound. APSP Journal of Case Reports, 2013: 4(3),44.


[3] Schär, M. O, Diaz-Romero, J, Kohl, S., Zumstein, M. A., & Nesic, D. Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro, 2015: 473(5).


[4] Jadhav, G. R., Shah, D., & Raghvendra, S. S. (2015). Autologous Platelet Rich Fibrin aided Revascularization of an immature, non-vital permanent tooth with apical periodontitis: A case report, 2015: 6(1).


[5] Pathak, H., Mohanty, S, Urs, A. B, Dabas, J. Treatment of Oral Mucosal Lesions by Scalpel Excision and Platelet-Rich Fibrin Membrane Grafting: A Review of 26 Sites. Journal of Oral and Maxillofacial Surgery, 2015; 73(9), 1865–1874.


[6] Kawase, T., Kamiya, M., Kobayashi, M., Tanaka, T., Okuda, K., Wolff, L. F., & Yoshie, H. The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2015; 103(4), 825–31.


[7] Sun, X.-L., Zhou, Y.-M., Zhao, J.-H., Zheng, L., & Yang, T. The effect of plateletrich fibrin on biologic characteristics of osteoblasts]. Shanghai Kou Qiang Yi Xue Shanghai Journal of Stomatology, 2015; 24(1), 61–4.


[8] Oliveira, M R., de Silva, A., Ferreira, S., Avelino, C, Garcia, I R, Mariano, R.. (2015). Influence of the association between platelet-rich fibrin and bovine bone on bone regeneration. A histomorphometric study in the calvaria of rats., 2015; 44(5).


[9] Hehn, J., Schwenk, T., Striegel, M., & Schlee, M. The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and first marginal bone loss around implants: results of a randomized, controlled clinical trial. International Journal of Implant Dentistry, 2016; 2(1), 13.


[10] Hatakeyama, I., Marukawa, E., Takahashi, Y., & Omura, K. Effects of platelet-poor plasma, platelet-rich plasma, and platelet-rich fibrin on the healing of extraction sockets with buccal dehiscence in dogs. Tissue Engineering. Part A, 2014; 20(3–4), 874–82.


[11] Jayadev, M., Marshal, Vr., Naik, Karunakar, P. Role of Platelet-rich fibrin in wound healing: A critical review. Journal of Conservative Dentistry, 2013; 16(4), 284.


[12] Fresno L, Fondevila, D., Bambo O, Chacaltana, A., García, F, Andaluz, A. Effects of platelet-rich plasma on intestinal wound healing in pigs. The Veterinary Journal, 2010; 185(3), 322–327.


[13] Doiphode AM, Hegde P, Mahindra U, Santhosh Kumar SM, Tendulkar PD, Tripathi V. Evaluation of the efficacy of platelet-rich plasma and platelet-rich fibrin in alveolar defects after removal of impacted bilateral mandibular third molars. Journal of International Society of Preventive & Community Dentistry, 2016; 6(Suppl 1), S47-52.