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Alekseeva, A., Enikolopova, E., Krotkova, O., Danilov, G., & Galkin, M. (2018). Dynamics of Cognitive Functions in Patients With Parasellar Meningiomas Undergoing Radiotherapy. KnE Life Sciences, 4(8), 42–48. https://doi.org/10.18502/kls.v4i8.3261

https://doi.org/10.18502/kls.v4i8.3261

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authors

  • A Alekseeva
    No author data available.
  • E Enikolopova
    No author data available.
  • O Krotkova
    No author data available.
  • G Danilov
    No author data available.
  • M Galkin
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Published Date

  • Nov 1, 2018

Dynamics of Cognitive Functions in Patients With Parasellar Meningiomas Undergoing Radiotherapy

KnE Life Sciences / The Fifth International Luria Memorial Congress «Lurian Approach in International Psychological Science» / Pages 42–48

Abstract

This study was focused on neuropsychological analysis of the cognitive functions in patients with parasellar meningiomas undergoing radiation therapy. In these patients, the unilateral hippocampus adjacent to the tumor was partially exposed to irradiation. A novel approach was used to assess particular memory functions
including pattern separation, in subpopulations of subjects prior to the course of radiotherapy, immediately after the course, and 1–2 years after therapy. Our results show a tendency for pattern separation decline in the long-term follow-up. A possible association of these disorders with the effect of the hippocampal region irradiation and inhibition of adult neurogenesis is discussed.



Keywords: cognitive functions, radiation therapy, hippocampus, parasellar meningioma, pattern separation, adult neurogenesis

References
[1] Greene-Schloesser, D., and Robbins, M. E. (2012). Radiation-induced cognitive impairment-from bench to bedside. Neuro-oncology, vol. 14, no. 4, pp. iv37–iv44.


[2] Gibson, E., and Monje, M. (2012). Effect of cancer therapy on neural stem cells: Implications for cognitive function. Current Opinion in Oncology, vol. 24, no. 6, pp. 672–678.


[3] Gondi, V., Tomé, W. A., and Mehta, M. P. (2010). Why avoid the hippocampus? A comprehensive review. Radiotherapy and Oncology, vol. 97, no. 3, pp. 370–376.


[4] Encinas, J. M., Michurina, T. V., Peunova, N., et al. (2011). Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell, vol. 8, no. 5, pp. 566–579.


[5] Spalding, K. L., Bergmann, O., Alkass, K., et al. (2013). Dynamics of hippocampal neurogenesis in adult humans. Cell, vol. 153, no. 6, pp. 1219–1227.


[6] Clelland, C. D., Choi, M., Romberg, C., et al. (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, vol. 325, no. 5937, pp. 210–213.


[7] Aimone, J. B., Deng, W., and Gage, F. H. (2011). Resolving new memories: A critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron, vol. 70, no. 4, pp. 589–596.


[8] Stark, S. M., Yassa, M. A., Lacy, J. W., et al. (2013). A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia, vol. 51, no. 12, pp. 2442–2449.


[9] Stark, S. M., Stevenson, R., Wu, C., et al. (2015). Stability of age-related deficits in the mnemonic similarity task across task variations. Behavioral neuroscience, vol. 129, no. 3, p. 257.


[10] Krotkova, O. A., Kaverina, M. Yu., and Danilov, G. V. (2016). Mozgovy‘e mexanizmy‘ raspredeleniya zritel‘nogo vnimaniya i vozmozhnost‘ korrekcii voznikayushhix pri porazhenii mozga narushenij s pomoshh‘yu texnologii ajtrekinga. V kn.: «Pyataya Mezhdunarodnaya konferenciya Fundamental‘ny‘e i prikladny‘e aspekty‘ vosstanovleniya soznaniya posle travmy‘ mozga: mezhdisciplinarny‘j podxod. Materialy‘ konferencii 30.06 – 01.07.2016», S. 56–58.