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Andriana, K., Aulia, I., & ., R. (2023). The Differences Between the Effect of Oral and Intraperitoneal Induction of Aluminum Chloride (AlCl3) on the Memory Function of White Rats (Rattus norvegicus strain wistar) Menopause Model. KnE Medicine, 3(2), 189–194. https://doi.org/10.18502/kme.v3i2.13051

https://doi.org/10.18502/kme.v3i2.13051

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authors

  • Kusuma Andriana

    Kusuma Andriana

    Department of Obstetric and Gynecology, Medical Faculty, University of Muhammadiyah Malang East Java – Indonesia
    https://orcid.org/0000-0002-4178-7116
  • Irma Aulia

    Irma Aulia

    Student of Medical Faculty, University of Muhammadiyah Malang – East Java – Indonesia
  • Rahayu .

    Rahayu .

    Department of Neurology, Medical Faculty, University of Muhammadiyah Malang – East Java – Indonesia

Published Date

  • Mar 8, 2023

The Differences Between the Effect of Oral and Intraperitoneal Induction of Aluminum Chloride (AlCl3) on the Memory Function of White Rats (Rattus norvegicus strain wistar) Menopause Model

KnE Medicine / 2nd International Conference on Medical Health Science (2nd ICMEDH) / Pages 189–194

Abstract

The decline in estrogen at menopause leads to a loss of neuroprotective function. One of the effects is Alzheimer’s disease (AD), with clinical manifestations of dementia, decreased memory function, language, thinking, and learning. The pathology of AD is widely studied but not completely understood. Various animal models have been used but have not been able to represent the pathology of AD fully. This study aimed to determine the effect of oral and intraperitoneal induction of aluminium chloride (AlCl3) on the memory function of menopausal model white rats (Rattus norvegicus strain wistar). This study used 16 female rats, divided into four groups, namely the negative control group (K1), the ovariectomy group (OVX, K2), and the OVX + AlCl.6H20 group 100 mg/kg BW orally (K3), and the OVX + AlCl3.6H20 group. 70 mg/kg body weight intraperitoneally. AlCl3.6H20 induction was given for six weeks. In the last five days, the Morris water maze test was carried out. From the MANOVA test, the p-value of F values in Pillai’s trace, Wilks‘ Lambda, Hotelling’a Trace, and Roy’s Largest Root were < 0.05. Based on the post hoc Bonferroni test on the fifth day of the trial, there was a significant difference between the standard and OVX groups with the AlCl3 induction group, and there was no significant difference between the oral and intraperitoneal induction groups. Conclusion: There is no significant effect of oral and intraperitoneal induction of Aluminum Chloride (AlCl3) on the memory function of white rats (Rattus norvegicus strain wistar) menopausal model.


Keywords: menopause, Alzheimer’s disease, memory test

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