Formation of a Closing Apparatus of the Lower Uterine Segment in Patients with Invasive Cervical Cancer after Radical Transabdominal Trachelectomy

Abstract

Strengthening of the lower uterine segment and formation of a “closing apparatus” for carrying a subsequent pregnancy in the absence of the cervix in patients with cervical cancer after conserving treatment in the amount of radical transabdominal trachelectomy. Materials and Research Methods: the study included 26 patients with cervical cancer of stage I in the reproductive age who received treatment in the amount of radical transabdominal trachelectomy (RTT). In the course of surgery in the amount of RTT, after an imposition of an utero-vaginal anastomosis, the strengthening of the lower uterine segment by setting and fixing a mesh of TiNi and its modelling within the range from the lower uterine segment to the upper third of the vagina was performed. Results: with regard to the issue of strengthening the utero-vaginal anastomosis, the implant takes over the function of the basic "closing apparatus" of the uterine and provides functional support and stability of the utero-vaginal anastomosis against the effects of intrauterine and intraperitoneal pressure. Conclusion: the usefulness of a mesh implant of the superelastic TiNi is due to its biomechanical properties: it is not absorbed, but gets fused with the surrounding tissue and provides resistance of tissues to excessive strain.

References
[1] E.L. Choinzonov, L.F. Pisareva, N.V. Cherduntseva, A.P. Boyarkina, I.N. Odintsova, N.A. Martynova, Cancer incidence in Siberia and the Russian Far East, Cancer care services, Bulletin of Siberian Branch of the Russian Academy of Medical Sciences [in Russian].2 (2004) 41-47.


[2] E.L. Choinzonov, L.F. Pisareva, L.D. Zhuikova, Cancer incidence in Tomsk region for the period from 2004 to 2009, Assessment of diagnosis quality, Siberian Journal of Oncoplogy [in Russian]. 3 (2011) 29-34.


[3] L.V. Adamyan, K.I. Zhordania, S.M. Beloborodov, Reproductive function in cancer patients, How to maintain ability to have children, Oncology Problems. 503 (2004) 279-292.


[4] I. Palaia, M. Pernice, M. Graziano, Neoadjuvant chemotherapy plus radical surgery in locally advanced cervical cancer during pregnancy: a case report, Am. J. Obstet. Gynecol. 197 (2007) 5-6.


[5] V.А. Antipov, E.G. Novikova, О.S. Balakhontseva, А.S. Shevchuk, Functional and anatomic rehabilitation after radical abdominal trachelectomy, Problems of reproduction, 1 (2010) 103-107.


[6] A.L. Chernyshova, A.Yu. Lyapunov, L.A. Kolomiets, V.I. Chernov, I.G. Sinilkin, Detection of sentinel lymph nodes in surgical treatment of cervical cancer, Siberian Journal of Oncology [in Russian]. 51 (2012) 28-33.


[7] L. Ungar, L. Palfalvi, R. Hogg, Abdominal radical trachelectomy: a fertility-preserving option for women with early cervical cancer, Br.J. Gynaecol. 112 (2005) 366-369.


[8] D. Dargent, Radical trachelectomy: an operation that preserves the fertility of young women with invasive cervicalcancer, Bull. Acad. Natl. Med. 185 (2001) 1295-304.


[9] L. Ungar, Update on radical abdominal trachelectomy, Abstracts of International Video Workshop on radical surgery in gynecological oncology, Prague, 2008.


[10] Dargent D, Martin X, Sacchetoni A. Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients // Cancer. 2000. 88:1877-1882.


[11] V.E. Gunther, Medical Materials and Shape Memory Implants [in Russian], MIC, Tomsk, 2013.


[12] V.A. Antipov, E.G. Novikova, О.S. Balakhontseva, А.S. Shevchuk, Radical abdominal trachelectomy: technical aspects, Oncology Problems. 56 (2010) 36-42.


[13] D. Dargent, Using radical trachelectomy to preserve fertility in early invasive cervical cancer, Contemporary OB/GYN, 2000, 23-49.


[14] E.G. Novikova, V.A. Antipov, E.A. Ronina, O.S. Balakhontseva, Radical abdominal trachelectomy, Russian Oncology Journal [in Russian]. 1 (2010) 8-14.


[15] A.L. Chernyshova, L.A. Kolomiets, S.E. Krasilnikov, Organ-preserving surgery for invasive cervical cancer, Siberian Journal of Oncology [in Russian]. 51 (2011) 72-78.


[16] A. Karam, N. Feldman, C.H. Holschneider, Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical cancer in pregnancy, Nat. Clin. Pract. Oncol. 4 (2007) 375-380.


[17] S. Alouini, K. Rida, P. Mathevet, Cervical cancer complicating pregnancy: implications of laparoscopic lymp hadenectomy, Gynecol Oncol. 108 (2008) 472-477.


[18] F. Amant, K. Van Calsteren, M. Halaska, Gynecologic Cancers in Pregnancy: Guidelines of an International Consensus Meeting, Int. J. Gynecol. Cancer. 19 (2009) 1-13.


[19] D. Dargent, J.L. Burn, M. Roy, I. Remi, Pregnancies following radical trachelectomy for invasive cervical cancer, Gynecol. Oncol. 52 (1994) 105.


[20] C.M. Salafia, V.K. Minior, J.A. Lopez-Zeno, S.S. Whittington, J.C. Pezzullo, A.M. Vintzileos, Relationship between placental histo, Int.J. Med. Sci. 20 (2010) 67-71.