The article describes the main directions of creation of unique technologies in medicine on the basis of new generation of biocompatible materials and implants with shape memory effect (SME). Physical and biological fundamentals and principles of creating a new class of biocompatible superelastic TiNi-based materials were drafted. Manufacturing technique of TiNi-based materials with using the induction melting technique, self-extending high-temperature synthesis and powder metallurgy with a certain complex of properties for various fields of medicine have been developed.