Effectiveness of Platelet Rich Fibrin (PRF) Compared with Conventional Therapy Toward Wound Dehiscence of Post-Operative Laparotomy


Objective: To compare the effectiveness of Platelet Rich Fibrin (PRF) and conventional therapy toward wound dehiscence of post-operative laparotomy in the Department of Obstetrics and Gynecology at Moewardi hospital.

Methods: This was a cross-sectional study conducted from September to December 2017 on obstetrics and gynecology post-laparotomy patients undergoing subtotal wound dehiscence in the Department of Obstetrics and Gynecology at Moewardi hospital from 2013 to 2017. They were divided into 2 groups, group 1 consisted of patients with subtotal wound dehiscence after obstetric and gynecological operation receiving conventional non-operative therapy, and group 2 was those having subtotal wound dehiscence after obstetrics and the gynecological operation receiving non-operative treatment with PRF. The data were analyzed using the T-test, performed by SPSS (Software Package for Social Science).

Results: There were 15 subjects in each group meeting the inclusion and exclusion criteria for both case and control groups. The statistical test showed that the average duration of wound healing in control group (12.60 about 2.58) was longer than in PRF group (7.0 about 3.52) with the significance of value p= 0.001 (p<0.05). The PRF group spent less cost (IDR 4.511.362 ± 2.977.934) compared with the conventional therapy group (IDR 12.540.735 ± 8.227.433) with p = 0.001 (p<0.05). Conclusions: Patients with PRF therapy had faster-wound healing duration, and the result was statistically significant with p=0.001 (p<0.05). PRF therapy also had more
cost-effectiveness compared with conventional therapy with p=0.001(p<0.05).

Keywords: Wound healing, Platelet-rich fibrin

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