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Swasono Hadi, N., Lestari, D., Farmawati, A., Ghozali, A., & Arsanti Lestari, L. (2019). The Relationship Between Systolic Blood Pressure and LDL Cholesterol Male Sprague Dawley Rats Given High Fat Diet and Mung Bean Sprouts (Phaseolus radiatus L.). KnE Life Sciences, 4(11), 26–35. https://doi.org/10.18502/kls.v4i11.3849

https://doi.org/10.18502/kls.v4i11.3849

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authors

  • N Swasono Hadi
    No author data available.
  • D Lestari
    No author data available.
  • A Farmawati
    No author data available.
  • A Ghozali
    No author data available.
  • L Arsanti Lestari
    No author data available.

Published Date

  • Mar 10, 2019

The Relationship Between Systolic Blood Pressure and LDL Cholesterol Male Sprague Dawley Rats Given High Fat Diet and Mung Bean Sprouts (Phaseolus radiatus L.)

KnE Life Sciences / The UGM Annual Scientific Conference Life Sciences 2016 / Pages 26–35

Abstract

Lifestyle changes with high fat food consumption are one of the factors the risks of cardiovascular diseases like coronary heart disease and atherosclerosis. The formation of atherosclerotic plaque in the walls of blood vessels initiated by the absorption of LDL through the blood to the endothelial cells that cause LDL is oxidized by the Reactive Oxygen Species, which initiated in the pathogenesis of human hypertension. Mung bean sprouts contain antioxidant compounds can be used as a functional food in the treatment of cardiovascular disease and hypertension. Male Sprague-Dawley was 24 at 8 wk and it is divided into four groups. The first group was given the standard diet, the second group was given a high-fat diet, the third group was given a high-fat diet, and mung bean sprouts 1 mL ⋅ 200 gBW−1, the fourth group was given a high-fat feed and
supplements of vitamin E dose of 23 IU. Blood pressure and LDL concentration were measured after the treatment. Systolic Blood pressure and levels of LDL cholesterol who were given mung bean sprouts and vitamin E has no statistical difference with group of normal. Levels of blood pressure and LDL cholesterol have a positive correlation. Mung Bean sprouts give the effect of a decrease in blood pressure and impeded elevated
levels of LDL male Sprague Dawley rats.



Keywords: Blood pressure, High fat diet, LDL cholesterol, Mung bean sprouts, Sprague Dawley rats.

References
[1] Wijaya A. Parameter biokimiawi untuk sindrom koroner akut (dalam) forum diagnisticum. [Biochemical parameters for acute coronary syndromes (in) diagnographic forums]. Prodia Educational Services. 2000:1–15. [in Bahasa Indonesia]. http://prodia. co.id/id


[2] Adam LB. Guidelines for adolescent nutrition service hyperlipidemia center of leadership, education, and training and child nutrition. Division of Epydemiology and Community Health, School of Public Health. University of Minnesota. 2006; 109-124 http://www.epi.umn.edu/let/pubs/adol_book.shtm


[3] Carey VJ, Bishop L, Laranjo N, Harshfield BJ, Kwiat C, Sacks FM. Contribution of high plasma triglicerides and low high-density lipoprotein cholesterol to residual risk of coronary heart disease after establishment of low density lipoprotein cholesetrol control. American Journal of Cardiology 2010;106:757–763. https://www.ncbi.nlm.
nih.gov/pubmed/20816113


[4] Muchtadi D. Pangan dan kesehatan jantung. [Food and heart health]. Alfabeta. Bandung;2013.p. 90–97. [in Bahasa Indonesia]. http://www.cvalfabeta.com/0412- detail-pangan_dan_kesehatan_jantung.html


[5] Yang R, Shi Y, Hao G, Li W, Le G. Increasing oxidative stress with progressive hyperlipidemia in human: Relation between malondialdehyde and atherogenic index. J. Clin Biochem. Nutr. 2008;43:154–115. https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2581765/


[6] Price SA, Wilson LM. Patofisiologi, konsep klinis proses-proses penyakit Ed. 6, Vol. 1. [Pathophysiology: Clinical concepts of disease processes 6