TY - JOUR AU - S V Stepanov AU - L Yu Dubov AU - Yu A Akmalova AU - V M Byakov AU - Yu V Shtotsky AU - A V Bokov PY - 2018/04/17 Y2 - 2024/03/29 TI - Carcinogenicity Screening of Chemicals Using Positron Annihilation Spectroscopy JF - KnE Energy JA - KEn VL - 3 IS - 2 SE - Articles DO - 10.18502/ken.v3i2.1854 UR - https://knepublishing.com/index.php/KnE-Energy/article/view/1854 AB - Chemical carcinogens are the main cause of cancer. Many thousands of new chemicals are synthesized annually in the world, unknown part of them is carcinogens. There are several methods, which are currently used for testing carcinogenicity. The fastest arephysicochemical methods. We suggest the method of fast carcinogen screening using the positron annihilation spectroscopy (PAS). It is based on the fact that the presence of carcinogens, being strong electrophiles, significantly decreases positronium (Ps) formation probability. This quantity can be measured by means of conventional PAS techniques: positron annihilation lifetime spectroscopy (PALS), angular correlation of annihilation radiation (ACAR) or Doppler broadening of annihilation radiation (DBAR). It is also possible to evaluate anti-carcinogenic properties of chemicals using the anti-inhibition effect of Ps formation.Keywords: carcinogen, electrophilicity, positron annihilation spectroscopy, positronium ER -