TY - JOUR AU - V N Morozov AU - A V Belousov AU - G A Krusanov AU - M A Kolyvanova AU - A P Chernyaev AU - A A Shtil PY - 2018/04/17 Y2 - 2024/03/29 TI - Secondary Electron Spectral Changes of Irradiated Gold Nanoparticle Caused By PEGylation JF - KnE Energy JA - KEn VL - 3 IS - 2 SE - Articles DO - 10.18502/ken.v3i2.1822 UR - https://knepublishing.com/index.php/KnE-Energy/article/view/1822 AB - Gold nanoparticles attract attention for the use in radiation therapy of tumors due to the ability to enhance the efficacy of ionizing radiation. The magnitude of the radiosensitizing effect depends on the parameters of the nanoparticle, in particular on the modification of the surface. In the present work, the spectrum of secondary particles generated in a gold nanoparticle virtually irradiated with 60Со gamma rays as a result of surface modification by a polyethylene glycol shell was studied. The Mont eCarlo calculations revealed that modification of the nanoparticle’s surface changes the spectrum of secondary particles. The most robust was the loss in low-energy electrons (51%) whereas the yield of Compton electrons increased by 1.27 times. At the same time, no statistically significant changes were observed in the spectrum of secondary photons and photoelectrons. Simulation of the formation and distribution of secondary electron radiation makes it possible to evaluate the parameters important for the rational design of antitumor nanoradiosensitizers based on chemical elements with a high atomic number.Keywords: gold nanoparticles, radiosensitizers, Monte-Carlo simulation, Geant4, radiation therapy, malignant tumors. ER -