Advances in Applied NanoBio-Technologies

Biomedical Potential of Bioactive Compounds from Sponges of the Persian Gulf: A Systematic Review

Fri, 20 Dec 2024 00:00:00 +0000

Sponges, among the oldest animals on Earth, are well-known for their ability to produce a wide array of bioactive compounds with diverse biomedical applications. The Persian Gulf, characterized by its extreme temperatures and high salinity, is home to a rich diversity of sponge species that have been found to produce numerous secondary metabolites. This review aims to provide a comprehensive overview of the sponge species identified in the Persian Gulf and their bioactive compounds. Given the unique environmental conditions of the Persian Gulf, including its high salinity and temperature, which influence the production of bioactive compounds, this review focuses on cataloging the sponge species found in this region and their recognized bioactive compounds. A thorough search was conducted using Google Scholar to gather data on the pharmacological properties of these compounds. The findings reveal that bioactive compounds derived from The Persian Gulf sponges possess significant therapeutic and pharmaceutical potential, including antibacterial, antifungal, anticancer, anti-inflammatory, and antioxidant activities. Additionally, some sponge species have been identified as biomarkers and purgatives. This review highlights the critical role of environmental factors such as salinity and temperature in influencing the production and efficacy of these bioactive compounds. The biomedical potential of these compounds and their prospects for contributing to new drug discoveries are also discussed, emphasizing the significance of The Persian Gulf sponges as a source of novel biological products.

Innovative Applications of Nanoparticles in Cancer Detection and Therapy

Mohadeseh Parhizkari — Fri, 20 Dec 2024 00:00:00 +0000

This paper investigates the role of gold nanoparticles (GNPs) in cancer diagnosis and treatment from a biometric perspective. Gold nanoparticles are recognized as crucial tools in biomedicine due to their unique properties, including controllable size, chemical stability, and the ability to conjugate with various biomolecules. This study employs data from the Web of Science to conduct a biometric analysis of related articles, examining research trends, scientific collaborations, and practical applications of GNPs in cancer diagnosis and treatment. The findings indicate that GNPs can be used as contrast agents in medical imaging techniques such as CT and MRI, enabling early cancer detection through their ability to target cancer cells. Additionally, GNPs can serve as drug carriers to deliver anti-cancer drugs precisely to target cells, enhancing treatment efficacy while minimizing unwanted side effects. The advantages of GNPs over other nanoparticles, such as high chemical stability and lower toxicity, are also highlighted. Despite significant advancements, further research is needed to understand molecular mechanisms, evaluate long-term effects, and improve GNP production methods. The results of this study demonstrate that gold nanoparticles have a high potential for improving cancer diagnosis and treatment, thereby contributing to the betterment of patient quality of life.

New Approach Graphene Oxide and Graphene Quantum Dots Based Nanocarriers for Treatment of Blood Cancer

Mohadeseh Parhizkari — Fri, 20 Dec 2024 00:00:00 +0000

In the Last years, graphene oxide and graphene quantum dots (GQDs) have received developed consideration due to their attributes such as small size and lightweight, fluorescence detection, liquid solvability, biomedicine, photo sensors, drug delivery, gene delivery, and cancer therapy refers to new approaches. Graphene quantum dots are fluorescent Graphene nanostructures with sizes Low. The fluorescence in GQDs emanates through two original fluorescence emissions from bond fracture energy transmission of interlace π-domains and in this material from surface deficiency. The GQDs have found applications in multiple areas such as nanomedicine. The GQDs have less toxicity and other particular properties in comparison to materials, quantum dots which make them superior properties for medical applications. In this review, the synthesis and fluorescence properties of the GQDs are illuminated and the latest progress in GQDs, Breast cancer therapy, their potential to pass Control Breast cancer, and Drug delivery are discussed. In this work, all studies and research are presented in the literature related to Blood cancer fighting using graphene and graphenebased conjugates. Performed a comprehensive summary of the latest progress of the graphene Blood cancer fight and highlighted the future challenges and the innovative possible theranostic applications.

New Approach in Nano Bio-active Materials in Cancer Therapy and Diagnosis Application

Raisa A. Aringazina, Afsaneh Hoseinzadeh — Fri, 20 Dec 2024 00:00:00 +0000

The emergence of nanotechnology has revolutionized the field of cancer therapy and diagnosis, offering new avenues for more efficient and targeted treatments. A novel approach in the development of nano-bioactive materials has shown promise in improving the precision and effectiveness of both cancer therapies and diagnostic techniques. These materials, which can range from nanoparticles to nanostructured biomaterials, possess unique properties such as enhanced surface area, tunable sizes, and the ability to interact with biological systems at a molecular level. In cancer therapy, nano-bioactive materials can be engineered to deliver drugs directly to cancerous cells, reducing systemic toxicity and minimizing side effects associated with conventional treatments. This targeted drug delivery is facilitated by the specific interactions between nanomaterials and the tumor microenvironment, allowing for controlled release of therapeutic agents. Additionally, the use of these materials in combination with imaging agents enables early detection and monitoring of tumor progression, enhancing diagnostic accuracy. The ability to functionalize nanoparticles with ligands that bind selectively to cancer cell markers further improves the specificity of diagnosis and therapy. Recent developments in the design of multifunctional nanobioactive materials are also paving the way for combined therapeutic strategies, such as chemotherapy, gene therapy, and immunotherapy, all in one platform. Furthermore, these advanced materials offer the potential for real-time monitoring of treatment efficacy, providing valuable insights into tumor behavior and treatment response. As research continues, nano-bioactive materials are poised to become a cornerstone in the next generation of cancer management, offering safer, more personalized, and highly effective solutions for both therapy and diagnosis.

Marine Biotechnology Progress and Policy in Iran

Amin Tamadon, Masoud Zare — Fri, 20 Dec 2024 00:00:00 +0000

This review provides a comprehensive overview of the current state and future directions of marine biotechnology development in Iran. It discusses the roles and responsibilities of key institutions involved in marine biotechnology, including the Offshore Knowledge Technology and Industries Development Headquarters, the Fisheries Organization of Iran, and the Environmental Protection Organization. The review highlights the strategic roadmap for marine technologies, focusing on natural compound extraction, marine biotechnology policies, and the establishment of research infrastructure. It addresses challenges in data collection, legal frameworks, and stakeholder coordination while emphasizing the need for improved research and development infrastructure, international collaboration, and effective policy-making. The review concludes with recommendations for enhancing marine biotechnology through government support, private sector involvement, and international cooperation, aiming to position Iran as a leader in this emerging field.